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Product Info Summary
| SKU: | A09440 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IHC-P, WB |
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Product info
Product Name
Anti-IQSEC2 Antibody
SKU/Catalog Number
A09440
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-IQSEC2 Antibody (Catalog # A09440). Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
IQSEC2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-IQSEC2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A09440)
Host
Rabbit
Contents
IQSEC2 antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
IQSEC2 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human IQSEC2. The immunogen is located within amino acids 1380 - 1430 of IQSEC2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
IQSEC2 antibody is human, mouse and rat reactive. At least two isoforms of IQSEC2 are known to exist; this antibody will only detect the larger isoform. IQSEC2 antibody is predicted to not cross-react with IQSEC1.
Reactive Species
A09440 is reactive to IQSEC2 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
162784 MW
Background of IQSEC2
ADP ribosylation factors (Arfs) are small GTP-binding proteins known for their role in vesicular transport, where they nucleate the assembly of coat protein complexes at sites of carrier vesicle formation. Similar to the related protein IQSEC1, IQSEC2 is a guanine nucleotide exchange protein for ARF1 and ARF6 that belongs to the BRAG family and contains one IQ domain, one PH domain and one SEC7 domain (1,2). IQSEC2 is a major component of the postsynaptic density (PSD) and colocalizes with PSD-95. It has been suggested to modulate the functions of the ARF proteins (1). Mutations in this gene have been implicated in nonsyndromic X-linked mental retardation (3).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A09440 is guaranteed for ELISA, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
IQSEC2 antibody can be used for detection of IQSEC2 by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of IQSEC2 in SK-N-SH cell lysate with IQSEC2 antibody at 1 μg/ml.
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Immunohistochemistry of IQSEC2 in mouse brain tissue with IQSEC2 antibody at 5 μg/ml.
Protein Target Info & Infographic
Gene/Protein Information For IQSEC2 (Source: Uniprot.org, NCBI)
Gene Name
IQSEC2
Full Name
IQ motif and SEC7 domain-containing protein 2
Weight
162784 MW
Superfamily
BRAG family
Alternative Names
IQ motif and Sec7 domain 2, Brefeldin-resistant Arf-GEF 1 protein, BRAG1, MRX1 IQSEC2 BRAG1, IQ-ArfGEF, MRX1, MRX18, MRX78 IQ motif and Sec7 domain ArfGEF 2 IQ motif and SEC7 domain-containing protein 2|IQ motif and Sec7 domain 2|brefeldin A resistant Arf-guanine nucleotide exchange factor 1|brefeldin A resistant Arf-guanine nucleotide exchange factor 1b|brefeldin A resistant Arf-guanine nucleotide exchange factor 1c|mental retardation, X-linked 18
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on IQSEC2, check out the IQSEC2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for IQSEC2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-IQSEC2 Antibody (A09440)
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