IQSEC2 Antibodies

AND IQSEC2 ELISA kits, IQSEC2 Proteins

Many biological assays use antibodies to detect IQSEC2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IQSEC2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IQSEC2 antibodies...

We validate the specificity of these antibodies to IQSEC2 by testing them on tissues known to express IQSEC2 positively and negatively. Browse below to find the IQSEC2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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IQSEC2 Infographic by Boster Bio

All IQSEC2 Products

Product

Figures

Specificity

Applications

Price

Anti-IQSEC2 Antibody

Human, Mouse, Rat

ELISA, IHC-P, WB

$449
Cat # A09440
0.1 mg

Anti-IQSEC2 Antibody (Center)

Human

$298
Cat # M09440
80 µl

IQSEC2 Overview

Facts about IQ motif and SEC7 domain-containing protein 2.

IQSEC2 3D structure. Source: alphafold

IQ motif and SEC7 domain-containing protein 2 (IQSEC2)

Is a guanine nucleotide exchange factor for the ARF GTP- binding proteins. .

Gene Information

Human
Gene Name:	IQSEC2
Uniprot:	Q5JU85
Entrez:	23096

Family

Belongs to:

BRAG family

Alternative Names

BRAG1; brefeldin A resistant Arf-guanine nucleotide exchange factor 1; brefeldin A resistant Arf-guanine nucleotide exchange factor 1c; IQ motif and Sec7 domain 2; IQ motif and SEC7 domain-containing protein 2; KIAA0522; MRX1

Molecular Weight

Mass (kDA):
162.784 kDA

Genomic Context


Human

Location:	Xp11.22
Sequence:	X; NC_000023.11 (53225784..53321356, complement)

Tissue Specificity

Expressed in brain, kidney and small intestine. Weakly expressed in placenta, pancreas, ovary, prostate and liver.

Subcellular Localizations

Cytoplasm.

Diseases

Nervousness
Spasm
Nervous System Disorder
Severe Mental Retardation
X-linked Infantile Spasm Syndrome
Infantile Spasms

PTMs

Ribosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IQSEC2

References

PMID: 26793055 by Kalscheuer V.M., et al. Novel missense mutation A789V in IQSEC2 underlies X-linked intellectual disability in the MRX78 family.

PMID: 20473311 by Shoubridge C., et al. Mutations in the guanine nucleotide exchange factor gene IQSEC2 cause nonsyndromic intellectual disability.