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Product Info Summary
| SKU: | A12113-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Iporin RUSC2 Antibody
SKU/Catalog Number
A12113-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Iporin RUSC2 Antibody (Catalog # A12113-1). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.
Storage & Handling
RUSC2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Iporin RUSC2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A12113-1)
Host
Rabbit
Contents
RUSC2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
RUSC2 antibody was raised against an 18 amino acid synthetic peptide from near the amino terminus of human RUSC2. The immunogen is located within amino acids 70 - 120 of RUSC2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least three isoforms are known to exist; this antibody will detect all three isoforms. This antibody is predicted to not cross-react with RUSC1.
Reactive Species
A12113-1 is reactive to RUSC2 in Human, Mouse
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
161225 MW
Background of RUSC2
RUSC2, also known as Iporin, shares with the related protein RUSC1 a common domain structure of RUN, leucine zipper and SH3 domain in addition to over 30% amino acid identity. RUSC2 is a rab1-interacting protein that also interacts with GM130, another rab1-interacting protein. RUSC2 interacts with specific rab1 isoforms with different rab-binding specificity. It has been suggested that RUSC2 may function as a link between the targeting of ER derived vesicles triggered by the rab1 GTPase and a signaling pathway composed of proteins containing SH3 and/or poly-proline regions.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A12113-1 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
RUSC2 antibody can be used for detection of RUSC2 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of RUSC2 in SK-N-SH cell lysate with RUSC2 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide
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Immunohistochemistry of RUSC2 in human brain tissue with RUSC2 antibody at 5 μg/mL.
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Immunofluorescence of RUSC2 in human brain tissue with RUSC2 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For RUSC2 (Source: Uniprot.org, NCBI)
Gene Name
RUSC2
Full Name
Iporin
Weight
161225 MW
Alternative Names
Iporin, KIAA0375, Iporin, Interacting protein of Rab1 RUSC2 Iporin, MRT61 RUN and SH3 domain containing 2 iporin|RUN and SH3 domain-containing protein 2|interacting protein of Rab1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on RUSC2, check out the RUSC2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for RUSC2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Iporin RUSC2 Antibody (A12113-1)
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