Anti-IL-17RA Antibody

Product Name

Anti-IL-17RA Antibody

View all IL-17RA/IL-17R Antibodies

SKU/Catalog Number

A01311

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-IL-17RA Antibody (Catalog # A01311). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

IL-17RA antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-IL-17RA Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01311)

Host

Rabbit

Contents

IL-17RA Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

IL-17RA antibody was raised against an 18 amino acid peptide near the amino terminus of human IL-17RA. The immunogen is located within amino acids 150 - 200 of IL-17RA.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

IL-17RA antibody is human, mouse and rat reactive. Multiple isoforms of IL-17RA are known to exist. This antibody is predicted to not cross-react with other IL-17 receptor subunits.

Reactive Species

A01311 is reactive to IL17RA in Human, Mouse, Rat

Reconstitution

Observed Molecular Weight

68 kDa

Calculated molecular weight

96122 MW

Background of IL-17RA/IL-17R

Interleukin 17A (IL-17A) is a proinflammatory cytokine secreted by activated T-lymphocytes (1). It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17RA is a ubiquitous type I membrane glycoprotein that binds with low affinity to IL-17A and IL-17F (1,2). IL-17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis (3,4). Defects in IL-17RA are the cause of familial candidiasis type 5 (CANDF5) which is a rare disorder with altered immune responses and impaired clearance of fungal infections (5).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A01311 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

IL-17RA antibody can be used for detection of IL-17RA by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

Gene/Protein Information For IL17RA (Source: Uniprot.org, NCBI)

Alternative Names

CD217, IL17R, CANDF5, CDw217, IL-17RA, hIL-17R, Interleukin-17 receptor A, IL-17 receptor A Il17ra|AW538159, Cdw217, Il, Il17r, VDw21, VDw217|interleukin 17 receptor A|interleukin-17 receptor A|IL-17 receptor A|IL-17RA

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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