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Product Info Summary
| SKU: | A01358-Dyl488 |
|---|---|
| Size: | 100 μg/vial |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | Flow Cytometry |
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Product info
Product Name
Anti-Human IDE DyLight® 488 conjugated Antibody
View all Insulysin/IDE Antibodies
SKU/Catalog Number
A01358-Dyl488
Size
100 μg/vial
Form
Liquid
Description
Boster Bio Anti-Human IDE DyLight® 488 conjugated Antibody catalog # A01358-Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human.
Storage & Handling
At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Cite This Product
Anti-Human IDE DyLight® 488 conjugated Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01358-Dyl488)
Host
Rabbit
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
Clonality
Polyclonal
Isotype
Rabbit IgG
Immunogen
E. coli-derived human IDE recombinant protein (Position: F485-K756).
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross-reactivity with other proteins.
Reactive Species
A01358-Dyl488 is reactive to IDE in Human
Reconstitution
Observed Molecular Weight
39 kDa
Calculated molecular weight
117.968kDa
Background of Insulysin/IDE
Insulin-degrading enzyme, also known as IDE, is an enzyme. This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A01358-Dyl488 is guaranteed for Flow Cytometry Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Flow Cytometry (Fixed), 1-3μg/1x106 cells
Validation Images & Assay Conditions
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Boster Kit Box
Protein Target Info & Infographic
Gene/Protein Information For IDE (Source: Uniprot.org, NCBI)
Gene Name
IDE
Full Name
Insulin-degrading enzyme
Weight
117.968kDa
Superfamily
peptidase M16 family
Alternative Names
Insulin-degrading enzyme; Abeta-degrading protease; Insulin protease; Insulinase; Insulysin; IDE IDE INSULYSIN insulin degrading enzyme insulin-degrading enzyme|Abeta-degrading protease|insulin protease|insulinase
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on IDE, check out the IDE Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for IDE: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Human IDE DyLight® 488 conjugated Antibody (A01358-Dyl488)
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