This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Insulin-degrading enzyme.
May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia. .
Human | |
---|---|
Gene Name: | IDE |
Uniprot: | P14735 |
Entrez: | 3416 |
Belongs to: |
---|
peptidase M16 family |
Abeta-degrading protease; EC 3.4.24; EC 3.4.24.56; FLJ35968; IDE; INSDEGM; Insulin protease; Insulinase; insulin-degrading enzyme; Insulysin
Mass (kDA):
117.968 kDA
Human | |
---|---|
Location: | 10q23.33 |
Sequence: | 10; NC_000010.11 (92451684..92574095, complement) |
Cytoplasm, cytosol. Cell membrane. Secreted. Present at the cell surface of neuron cells. The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform.
PMID: 3059494 by Affholter J.A., et al. Human insulin-degrading enzyme shares structural and functional homologies with E. coli protease III.
PMID: 2293021 by Affholter J.A., et al. Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes.
*More publications can be found for each product on its corresponding product page