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Product Info Summary
| SKU: | A06927 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, WB |
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Product info
Product Name
Anti-Grik3 Antibody
View all GluR7/GRIK3 Antibodies
SKU/Catalog Number
A06927
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Grik3 Antibody (Catalog # A06927). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Grik3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Grik3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A06927)
Host
Rabbit
Contents
Grik3 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Grik3 antibody was raised against a 13 amino acid synthetic peptide near the amino terminus of the human Grik3. The immunogen is located within amino acids 30 - 80 of Grik3.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least three isoforms of EVER2 are known to exist; this antibody will only recognize the larger isoform. EVER2 has no cross-reactivity to EVER1.
Reactive Species
A06927 is reactive to GRIK3 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
104037 MW
Background of GluR7/GRIK3
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik3, also known as glutamate receptor 7, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik3 is highly homologous to the related ionotrophic glutamate receptors Grik2 and Grik1. Grik3 has recently been shown to be an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses as grik3-null mice show significantly reduced short- and long-term synaptic potentiation. Other reports have suggested that different polymorphisms in the Grik3 protein may be associated with neurological defects such as recurrent major depressive disorder and schizophrenia. This Grik3 antibody does not cross-react with Grik2.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A06927 is guaranteed for ELISA, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Grik3 antibody can be used for detection of Grik3 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of Grik3 in human brain tissue lysate with Grik3 antibody at (A) 1 and (B) 2 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For GRIK3 (Source: Uniprot.org, NCBI)
Gene Name
GRIK3
Full Name
Glutamate receptor ionotropic, kainate 3
Weight
104037 MW
Superfamily
glutamate-gated ion channel (TC 1.A.10.1) family
Alternative Names
EAA5, GLR7, GLUR7, GluK3, GluR7a, Glutamate receptor ionotropic, kainate 3, Excitatory amino acid receptor 5 GRIK3 EAA5, GLR7, GLUR7, GluK3, GluR7a glutamate ionotropic receptor kainate type subunit 3 glutamate receptor ionotropic, kainate 3|dJ1090M5.1 (glutamate receptor, ionotropic, kainate 3 (GLUR7))|excitatory amino acid receptor 5|gluR-7|glutamate receptor 7
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on GRIK3, check out the GRIK3 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for GRIK3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Grik3 Antibody (A06927)
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