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Product Info Summary
| SKU: | A06001-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Grik1 Antibody
View all GluR5/GRIK1 Antibodies
SKU/Catalog Number
A06001-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Grik1 Antibody (Catalog # A06001-1). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Grik1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Grik1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A06001-1)
Host
Rabbit
Contents
Grik1 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Grik1 antibody was raised against a 16 amino acid synthetic peptide near the center of the human Grik1. The immunogen is located within amino acids 380 - 430 of Grik1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
PMEPA1 antibody is human, mouse and rat reactive. At least four isoforms are known to exist; this antibody will detect all of the isoforms.
Reactive Species
A06001-1 is reactive to GRIK1 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
103981 MW
Background of GluR5/GRIK1
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik1, also known as glutamate receptor 5, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik1 is expressed in GABAergic interneurons of the hippocampus and are thought to participate in the formation of various subtypes of kainate receptors with Grik2 and KA2. Stimulation of Grik1 leads to intracellular calcium release and activation of protein kinase C. Excessive activation has been associated with psychiatric, neurological and neurodegenerative diseases. Numerous isoforms of Grik1 are known to exist and may be subject to RNA editing within the second transmembrane domain, which is thought to alter the properties of ion flow.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A06001-1 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Grik1 antibody can be used for detection of Grik1 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of Grik1 in rat brain tissue lysate with Grik1 antibody at (A) 0.5 and (B) 1 μg/mL.
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Immunohistochemical staining of human brain tissue using Grik1 antibody at 2.5 μg/mL.
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Immunofluorescence of Grik1 in Human Brain cells with Grik1 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For GRIK1 (Source: Uniprot.org, NCBI)
Gene Name
GRIK1
Full Name
Glutamate receptor ionotropic, kainate 1
Weight
103981 MW
Superfamily
glutamate-gated ion channel (TC 1.A.10.1) family
Alternative Names
EAA3, EEA3, GLR5, GLUR5, GluK1, Glutamate receptor ionotropic, kainate 1, Excitatory amino acid receptor 3 GRIK1 EAA3, EEA3, GLR5, GLUR5, GluK1, gluR-5 glutamate ionotropic receptor kainate type subunit 1 glutamate receptor ionotropic, kainate 1|excitatory amino acid receptor 3|glutamate receptor 5
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on GRIK1, check out the GRIK1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for GRIK1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Grik1 Antibody (A06001-1)
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