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Key=sku, value=A01663
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Key=created_at, value=2020-03-11 06:18:50
Key=updated_at, value=2024-09-26 01:03:36
Key=mst_search_weight, value=0
Key=status, value=Enabled
Key=name, value=Anti-GRB10 Antibody
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Key=is_recurring, value=No
Key=visibility, value=Catalog, Search
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Key=featured, value=No
Key=featured_image, value=Yes
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Key=template, value=antibodies
Key=host, value=Rabbit
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Key=price, value=449.0000
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Key=meta_title, value=Anti-GRB10 Antibody A01663
Key=meta_description, value=Boster Bio Anti-GRB10 Antibody (Catalog # A01663). Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat. Supplied as 0.1 mg in Liquid form antibody.
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Key=url_key, value=anti-grb10-antibody-a01663-boster
Key=url_path, value=anti-il-8-antibody-a00423-boster
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Key=msrp_display_actual_price_type, value=Use config
Key=gift_message_available, value=No
Key=size, value=0.1 mg
Key=protein_name, value=Growth factor receptor-bound protein 10
Key=gene_full_name, value=Growth factor receptor-bound protein 10
Key=uniprot_id, value=Q13322
Key=sensitivity
Key=applications, value=ELISA, IF, WB
Key=reactivity, value=Human, Mouse, Rat
Key=form, value=Liquid
Key=concentration, value=1 mg/mL
Key=cross_reactivity, value=At least three isoforms of GRB10 are known to exist; this antibody will detect all three isoforms.
Key=clone_number
Key=predicted_reactivity, value=Pig
Key=source_company, value=Prosci 6733; Cost: 249
Key=isotype, value=IgG
Key=molecular_weight, value=67231 MW
Key=sample_size_available, value=25ug for $99, contact us for details
Key=related_product_skus, value=EK0413,PB9621,PROTP10145,PROTP10145-1,PROTP10145-2,PROTP10145-3,PROTP19874,PROTP26894,PROTP41324,PROTP67813
Key=product_category, value=Primary Antibodies
Key=research_category, value=Signal Transduction
Key=clonality, value=Polyclonal
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Key=rating_value, value=100
Key=review_count, value=6
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Key=cj_related_products, value=Beckwith-wiedemann Syndrome:PB9937^Growth Disorders:EK0776^Regulation Of Growth:PB9400|A01584|PA1841^Russell-silver Syndrome:A03240-1
Key=description, value=Boster Bio Anti-GRB10 Antibody (Catalog # A01663). Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat.
Key=short_description, value=Boster Bio Anti-GRB10 Antibody (Catalog # A01663). Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat.
Key=meta_keyword, value=Anti-GRB10 Antibody
Key=contents, value=GRB10 Antibody is supplied in PBS containing 0.02% sodium azide.
Key=background, value=GRB10 belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules and function in diverse cellular processes. GRB10 is a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of GRB10 inhibits tyrosine kinase activity and results in growth suppression. GRB10 can also interact with the L isoform of the proapoptotic protein Bim. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts.
Key=gene_name, value=GRB10
Key=synonyms, value=RSS, IRBP, MEG1, GRB-IR, Grb-10, GRBIR, KIAA0207, Growth factor receptor-bound protein 10, GRB10 adapter protein
Key=application_details, value=GRB10 antibody can be used for detection of GRB10 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunofluorescence starting at 20 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in rat samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Key=subcellular_localization, value=Cytoplasm . When complexed with NEDD4 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the sorting of the receptor to the lysosomal compartment (By similarity). .
Key=tissue_specificity, value=Widely expressed in fetal and adult tissues, including fetal and postnatal liver, lung, kidney, skeletal muscle, heart, spleen, skin and brain.
Key=protein_function, value=Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin- stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin- stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2.
Key=application_notes
Key=description_before_attributes
Key=competitor_equivalent_skus, value=sc 25342|sc 55462|sc 7165|sc 4600|sc 73321|sc 7922|sc 1269|sc 376750|sc 8427|sc 7302|sc 52870|sc 101499|sc 32817|sc 71367
Key=immunogen, value=GRB10 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human GRB10. The immunogen is located within amino acids 440 - 490 of GRB10.
Key=purification, value=GRB10 Antibody is affinity chromatography purified via peptide column.
Key=storage, value=GRB10 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Key=custom_attribute_1, value=68 kDa
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