This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
GRB10 Antibodies
AND GRB10 ELISA kits, GRB10 Proteins
Many biological assays use antibodies to detect GRB10, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GRB10 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GRB10 antibodies...
Previous: CBLIF
Next: RAPGEF1
GRB10 Infographic by Boster Bio
All GRB10 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$480
Cat # EKC1250
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1250
1 kit, containing one 96-well plate and all necessary reagents
Human
ELISA
$540
Cat # EKC2287
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2287
1 kit, containing two 96-well plates and all necessary reagents
Human, Monkey, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A01663-2
100 μg/vial
Cat # A01663-2
100 μg/vial
Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A01663-3
100 μg/vial
Cat # A01663-3
100 μg/vial
Human, Monkey, Rat
Flow Cytometry, WB
$370
Cat # M01663
100 μg/vial
Cat # M01663
100 μg/vial
Human, Mouse, Rat
IHC, WB
$523
Cat # M01663-1
100 µl
Cat # M01663-1
100 µl
GRB10 Overview
Facts about Growth factor receptor-bound protein 10.
Growth factor receptor-bound protein 10 (GRB10)
Adapter protein that modulates coupling of a number of cell surface receptor kinases with particular signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors.
The inhibitory effect can be achieved by two mechanisms: interference with the signaling pathway and enhanced receptor degradation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin- stimulated IRS1 and IRS2 tyrosine phosphorylation.
Gene Information
| Human | |
|---|---|
| Gene Name: | GRB10 |
| Uniprot: | Q13322 |
| Entrez: | 2887 |
Family
| Belongs to: |
|---|
| GRB7/10/14 family |
Alternative Names
GRB10 adapter protein; GRB10 adaptor protein; Grb-10; GRBIR; GRB-IR; growth factor receptor-bound protein 10; Insulin receptor-binding protein Grb-IR; IRBP; KIAA0207; maternally expressed gene 1; MEG1; RSS
Molecular Weight
Mass (kDA):
67.231 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7p12.1 |
| Sequence: | 7; NC_000007.14 (50590068..50793453, complement) |
Tissue Specificity
Widely expressed in fetal and adult tissues, including fetal and postnatal liver, lung, kidney, skeletal muscle, heart, spleen, skin and brain.
Subcellular Localizations
Cytoplasm. When complexed with NEDD4 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the sorting of the receptor to the lysosomal compartment (By similarity).
Diseases
- Russell-silver Syndrome
- Malignant Neoplasms
- Neoplasms
- Growth Disorders
- Uniparental Disomy
- Diabetes Mellitus
- Benign Mixed Epithelial And Stromal Tumor Of Kidney
- Growth Retardation
- Fetal Growth Retardation
- Beckwith-wiedemann Syndrome
- Diabetes Mellitus, Non-insulin-dependent
- Cell Transformation, Neoplastic
- Tissue Adhesions
Interacting Proteins
- EPHB1
- FLT3
- INSR
- PIK3R1
- RCAN3
Pathways
- Methylation
- Dna Methylation
- Cell Migration
- Cell Proliferation
- Pathogenesis
- Cell Cycle
- Transport
- Localization
- Cell Growth
- Angiogenesis
- Regulation Of Growth
- Cell Death
- Secretion
PTMs
- Phosphorylation
- Methylation
Research Areas
- Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GRB10
bosterbio.com/bosterbio-gene-info-cards/GRB10
References
PMID: 7479769 by Liu F., et al. Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function.
PMID: 8798417 by O'Neill T.J., et al. Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling.