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Product Info Summary
| SKU: | M00353-1 |
|---|---|
| Size: | 100 μl |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | IP, IF, IHC, ICC |
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Product info
Product Name
Anti-Granzyme B GZMB Monoclonal Antibody
View all Granzyme B Antibodies
SKU/Catalog Number
M00353-1
Size
100 μl
Form
Liquid
Description
Boster Bio Anti-Granzyme B GZMB Monoclonal Antibody catalog # M00353-1. Tested in IHC, ICC/IF, IP applications. This antibody reacts with Human.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Granzyme B GZMB Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M00353-1)
Host
Rabbit
Contents
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Clonality
Monoclonal
Clone Number
AAHC-7
Isotype
Rabbit IgG
Immunogen
A synthesized peptide derived from human Granzyme B This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
M00353-1 is reactive to GZMB in Human
Reconstitution
Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL
Observed Molecular Weight
23 kDa
Calculated molecular weight
132494 MW
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
M00353-1 is guaranteed for IP, IF, IHC, ICC Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
IHC 1:50-1:200
ICC/IF 1:50-1:200
IP 1:50
Positive Control
IHC: human T cell lymphoma tissue
Validation Images & Assay Conditions
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Immunohistochemical analysis of paraffin-embedded human T cell lymphoma, using Granzyme B Antibody.
Protein Target Info & Infographic
Gene/Protein Information For GZMB (Source: Uniprot.org, NCBI)
Gene Name
GZMB
Full Name
Granzyme B
Weight
132494 MW
Superfamily
peptidase S1 family
Alternative Names
Leptin receptor;LEP-R;HuB219;OB receptor;OB-R;CD295;LEPR;DB, OBR; GZMB C11, CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT granzyme B granzyme B|T-cell serine protease 1-3E|cathepsin G-like 1|cytotoxic T-lymphocyte proteinase 2|cytotoxic serine protease B|fragmentin 2|granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)|human lymphocyte protein
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on GZMB, check out the GZMB Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for GZMB: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Granzyme B GZMB Monoclonal Antibody (M00353-1)
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