Anti-Granzyme B GZMB Monoclonal Antibody

Product Name

Anti-Granzyme B GZMB Monoclonal Antibody

View all Granzyme B Antibodies

SKU/Catalog Number

M00353-1

Size

100 μl

Form

Liquid

Description

Boster Bio Anti-Granzyme B GZMB Monoclonal Antibody catalog # M00353-1. Tested in IHC, ICC/IF, IP applications. This antibody reacts with Human.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Granzyme B GZMB Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M00353-1)

Host

Rabbit

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Clonality

Monoclonal

Clone Number

AAHC-7

Isotype

Rabbit IgG

Immunogen

A synthesized peptide derived from human Granzyme B This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

M00353-1 is reactive to GZMB in Human

Applications

M00353-1 is guaranteed for IP, IF, IHC, ICC Boster Guarantee

Observed Molecular Weight

23 kDa

Calculated molecular weight

132494 MW

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

IHC 1:50-1:200
ICC/IF 1:50-1:200
IP 1:50

Validation Images & Assay Conditions

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Immunohistochemical analysis of paraffin-embedded human T cell lymphoma, using Granzyme B Antibody.

Gene/Protein Information For GZMB (Source: Uniprot.org, NCBI)

Alternative Names

C11; CCPI; CGL1; CGL-1; CSPB; CSP-B; CTLA1; CTLA-1; CTSGL1; Fragmentin-2; Granzyme B; Granzyme-2; GRB; GrzB; GZMB; HLP; SECT GZMB C11, CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT granzyme B granzyme B|T-cell serine protease 1-3E|cathepsin G-like 1|cytotoxic T-lymphocyte proteinase 2|cytotoxic serine protease B|fragmentin 2|granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)|human lymphocyte protein

For more info on GZMB, check out the GZMB Infographic

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In this infographic, you will see the following information for GZMB: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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