Anti-Granzyme A/GZMA Antibody Picoband®

Product Name

Anti-Granzyme A/GZMA Antibody Picoband®

View all Granzyme A Antibodies

SKU/Catalog Number

PA1588

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-Granzyme A/GZMA Antibody catalog # PA1588. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Granzyme A/GZMA Antibody Picoband® (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1588)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human Granzyme A.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PA1588 is reactive to GZMA in Human

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Observed Molecular Weight

22-26 kDa

Calculated molecular weight

28999 MW

Background of Granzyme A

Granzyme A is a protein that in humans is encoded by the GZMA gene. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are though to protect their host by lysing cells bearing on their surface "nonself" antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. GZMA induces caspase-independent apoptosis in a characteristic manner, except it causes a distinctive form of DNA damage: single-stranded DNA nicking. A target of GZMA is the SET complex, including HMGB2 and ANP32A .

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

PA1588 is guaranteed for IHC, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, By Heat
Western blot, 0.1-0.5μg/ml, Human

Positive Control

WB: JURKAT Cell, CEM Cell, RAJI Cell
IHC: Human Tonsil Tissue

Validation Images & Assay Conditions

Gene/Protein Information For GZMA (Source: Uniprot.org, NCBI)

Alternative Names

Granzyme A;3.4.21.78;CTL tryptase;Cytotoxic T-lymphocyte proteinase 1;Fragmentin-1;Granzyme-1;Hanukkah factor;H factor;HF;GZMA;CTLA3, HFSP; GZMA CTLA3, HFSP granzyme A granzyme A|CTL tryptase|Cytotoxic T-lymphocyte-associated serine esterase-3|Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; Hanukah factor serine protease)|HF|Hanukah factor serine protease)|cytotoxic T-lymphocyte proteinase 1|fragmentin-1|granzyme 1|granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)|h factor

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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