Anti-GCSF Receptor/CSF3R Antibody Picoband®

Product Name

Anti-GCSF Receptor/CSF3R Antibody Picoband®

View all G-CSFR/CD114 Antibodies

SKU/Catalog Number

PA1906

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-GCSF Receptor/CSF3R Antibody catalog # PA1906. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-GCSF Receptor/CSF3R Antibody Picoband® (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1906)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human GCSF Receptor.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PA1906 is reactive to CSF3R in Human

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Observed Molecular Weight

108 kDa

Calculated molecular weight

92156 MW

Background of G-CSFR/CD114

CSF3R (Colony-Stimulating Factor 3 Receptor, Granulocyte) also known as GCSFR or CD114 ( (Cluster of Differentiation 114) is a protein that in humans is encoded by the CSF3R gene. G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF). The G-CSF receptors belongs to a family of cytokine receptors known as the hematopoietin receptor family. The CSF3R gene consists of 17 exons. By in situ hybridization using human CSF3R cDNA as a probe, Inazawa et al. (1991) localized the gene to 1p35-p34.3. The G-CSF-R is a transmembrane receptor that consists of an extracellular ligand-binding portion, a transmembrane domain, and the cytoplasmic portion that is responsible for signal transduction. GCSF-R ligand-binding is associated with dimerization of the receptor and signal transduction through proteins including Jak, Lyn, STAT, and Erk1/2. Dong et al. (2001) reported that the C terminus of CSF3R is required for SHP1 downregulation of CSF3-induced STAT activation. The authors proposed that this mechanism inhibits cell proliferation and survival in response to CSF3.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

PA1906 is guaranteed for WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blot, 0.1-0.5μg/ml, Human

Positive Control

WB: Human Placenta Tissue

Validation Images & Assay Conditions

Gene/Protein Information For CSF3R (Source: Uniprot.org, NCBI)

Alternative Names

Granulocyte colony-stimulating factor receptor;G-CSF receptor;G-CSF-R;CD114;CSF3R;GCSFR; CSF3R CD114, GCSFR, SCN7 colony stimulating factor 3 receptor granulocyte colony-stimulating factor receptor|CD114 |G-CSF receptor|G-CSF-R|colony stimulating factor 3 receptor (granulocyte)

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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