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Product Info Summary
| SKU: | A13756 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, WB |
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Product info
Product Name
Anti-GAS PAGR1 Antibody
SKU/Catalog Number
A13756
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-GAS PAGR1 Antibody (Catalog # A13756). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.
Storage & Handling
GAS antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-GAS PAGR1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A13756)
Host
Rabbit
Contents
GAS Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
GAS antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human GAS. The immunogen is located within the last 50 amino acids of GAS.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least two isoforms of Paralemmin3 are known to exist; this antibody will only detect the longer isoform
Reactive Species
A13756 is reactive to PAGR1 in Human, Mouse
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
27716 MW
Background of PA1
Steroid receptor co-activators (SRCs) were initially described as nuclear receptor transcription co-activators, but they have recently been determined to co-regulate transcription initiated by other transcription factors. GAS is a recently identified glutamate-rich protein that interacts with SRC1, but not GRIP1 or AIB1, the other two members of the SRC family. GAS can also interact with the alpha subunit of the estrogen receptor (ERalpha), but not other receptors such as the retinoic acid receptor a, suggesting the interaction between GAS and ERalpha is relatively specific. Depletion of GAS by RNA interference in MCF7 cells led to a decrease in the mRNA and protein levels of ER target genes such as pS2, c-Myc and cyclin D1, indicating the role of GAS in the regulation of ER target genes. GAS has also been found to associate with an SET1-like methyltransferase complex specific for H3K4 methylation, suggesting that GAS has multiple roles in transcriptional regulation.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A13756 is guaranteed for ELISA, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
GAS antibody can be used for detection of GAS by Western blot at 1 μg/mL.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of GAS in EL4 cell lysate in (A) the absence and (B) the presence of blocking peptide with GAS antibody at 1μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For PAGR1 (Source: Uniprot.org, NCBI)
Gene Name
PAGR1
Full Name
PAXIP1-associated glutamate-rich protein 1
Weight
27716 MW
Alternative Names
GAS, PA1, C16orf53, PAXIP1-associated glutamate-rich protein 1, PAXIP1-associated protein 1 PAGR1 C16orf53, GAS, PA1 PAXIP1 associated glutamate rich protein 1 PAXIP1-associated glutamate-rich protein 1|PAXIP1-associated protein 1|PTIP-associated 1 protein|PTIP-associated protein 1|glutamate-rich coactivator associated with SRC1|glutamate-rich coactivator interacting with SRC1|glutamate-rich coactivator interacting with SRC1/NCOA1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on PAGR1, check out the PAGR1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for PAGR1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-GAS PAGR1 Antibody (A13756)
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