Key=store_id
Key=entity_id, value=101193
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Key=type_id, value=simple
Key=sku, value=A00227-2
Key=has_options, value=1
Key=required_options, value=1
Key=created_at, value=2021-03-12 20:07:47
Key=updated_at, value=2024-10-31 05:02:18
Key=mst_search_weight, value=0
Key=status, value=Enabled
Key=name, value=Anti-GAPDH Antibody (C-term R248)
Key=cj_search_index
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Key=is_recurring, value=No
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Key=featured, value=No
Key=featured_image, value=Yes
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Key=free_shipping, value=No
Key=template, value=antibodies
Key=host, value=Rabbit
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Key=yoast_keyword_score, value=-1205
Key=yoast_content_score, value=30
Key=price, value=299.0000
Key=weight, value=1.0000
Key=meta_title, value=Anti-GAPDH Antibody (C-term R248) | Boster
Key=meta_description, value=Boster Bio Anti-GAPDH Antibody (C-term R248) (Catalog # A00227-2). Tested in WB, IF, Flow Cytometry, IHC-P application(s). This antibody reacts with Human.
Key=image, value=/C/G/CGB-primary-antibodies-M30373-IHC-testing-1.jpg
Key=small_image, value=/C/G/CGB-primary-antibodies-M30373-IHC-testing-1.jpg
Key=thumbnail, value=/C/G/CGB-primary-antibodies-M30373-IHC-testing-1.jpg
Key=url_key, value=anti-gapdh-antibody-c-term-r248-a00227-2-boster
Key=url_path, value=anti-hcg-beta-pregnancy-choriocarcinoma-marker-antibody-m30373-boster
Key=options_container, value=Block after Info Column
Key=image_label, value=Formalin-fixed, paraffin-embedded human Placenta stained withhCG beta Ab (HCGb/54 + HCGb/459).
Key=small_image_label, value=Formalin-fixed, paraffin-embedded human Placenta stained withhCG beta Ab (HCGb/54 + HCGb/459).
Key=thumbnail_label, value=Formalin-fixed, paraffin-embedded human Placenta stained withhCG beta Ab (HCGb/54 + HCGb/459).
Key=msrp_display_actual_price_type, value=Use config
Key=gift_message_available, value=No
Key=size, value=80 µl
Key=protein_name, value=Cluster of differentiation 14
Key=gene_full_name, value=Choriogonadotropin subunit beta
Key=uniprot_id, value=P04406
Key=sensitivity
Key=applications, value=Flow Cytometry, IF, IHC-P, WB
Key=reactivity, value=Human
Key=form, value=Liquid
Key=cross_reactivity, value=No cross reactivity with other proteins.
Key=recommended_detection_systems, value=Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
Key=predicted_reactivity, value=Chicken, Mouse, Pig, Rat
Key=source_company, value=Abcepta AP7873b-ev: 75| AP7873b: 192.5
Key=isotype, value=Rabbit IgG
Key=molecular_weight, value=36053 Da
Key=sample_size_available, value=20ug for $99, contact us for details
Key=related_product_skus, value=MA1111
Key=product_category, value=Primary Antibodies
Key=research_category, value=Cancer, Metabolism, Microbiology, Neuroscience, Signal Transduction
Key=clonality, value=Polyclonal
Key=swatch_image, value=/antibody/ek1125-2-ELISA-mouse-ccl6-c10-picokine-elisa-kit.jpg
Key=rating_value, value=95
Key=review_count, value=2
Key=mp_exclude_sitemap, value=No
Key=cj_related_products, value=DNA Repair:A13037^Loading Controls:M01263-2^Nuclear Receptors, Coactivators and Corepressors:A00227|A00227-1|M00227-1|PROTP04406
Key=description, value=Boster Bio Anti-GAPDH Antibody (C-term R248) (Catalog # A00227-2). Tested in WB, IF, Flow Cytometry, IHC-P application(s). This antibody reacts with Human.
Key=short_description, value=Boster Bio Anti-GAPDH Antibody (C-term R248) (Catalog # A00227-2). Tested in WB, IF, Flow Cytometry, IHC-P application(s). This antibody reacts with Human.
Key=meta_keyword, value=Anti-GAPDH Antibody (C-term R248)
Key=contents, value=Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Key=background, value=GAPDH catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The enzyme exists as a tetramer of identical chains.
Key=gene_name, value=GAPDH
Key=synonyms, value=Glyceraldehyde-3-phosphate dehydrogenase, GAPDH, Peptidyl-cysteine S-nitrosylase GAPDH, 2699-, GAPDH, GAPD
Key=application_details, value=IF: 1:10-1:50
WB: 1:1000
IHC-P: 1:50-1:100
FC: 1:10-1:50
Key=subcellular_localization, value=Cytoplasm, cytosol. Nucleus {ECO:0000250|UniProtKB:P04797}. Cytoplasm, perinuclear region. Membrane Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P04797} Note=Translocates to the nucleus following S-nitrosylation and interaction with SIAH1, which contains a nuclear localization signal (By similarity). Postnuclear and Perinuclear regions (PubMed:12829261) {ECO:0000250|UniProtKB:P04797, ECO:0000269|PubMed:12829261}
Key=tissue_specificity, value=Brain, heart, placenta, pancreas and skeletal muscle. Expressed to a lesser extent in lung, liver and kidney
Key=protein_function, value=Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:3170585, PubMed:11724794). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D- glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:3170585, PubMed:11724794). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1- dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (By similarity). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity).
Key=competitor_equivalent_skus, value=sc 23928|sc 59873|sc 59872|sc 52390
Key=immunogen, value=This GAPDH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 233-259 amino acids from the C-terminal region of human GAPDH.
Key=purification, value=This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Key=storage, value=Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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