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Product Info Summary
| SKU: | A15565 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-FRMPD4 TMEM94 Antibody
View all Preso/FRMPD4 Antibodies
SKU/Catalog Number
A15565
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-FRMPD4 Antibody (Catalog # A15565). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.
Storage & Handling
FRMPD4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-FRMPD4 TMEM94 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A15565)
Host
Rabbit
Contents
FRMPD4 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
FRMPD4 antibody was raised against an 18 amino acid synthetic peptide from near the center of human FRMPD4. The immunogen is located within amino acids 620 - 670 of FRMPD4.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
TYW2 antibody is predicted to not cross-react with other TYW protein family members. At least two isoforms of TYW2 are known to exist; this antibody will detect both isoforms
Reactive Species
A15565 is reactive to FRMPD4 in Human
Reconstitution
Calculated molecular weight
144,379 MW
Background of Preso/FRMPD4
The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD4, also known as Preso, also contains another protein interaction domain termed WW (domain with two conserved Trp residues) at its amino terminus. It was identified through a yeast two-hybrid screen using the PDZ domain of PSD-95 as bait and is highly expressed in multiple regions of the brain and is enriched in the postsynaptic density (PSD) fractions. Overexpression of FRMPD4 in cultured hippocampal neurons significantly increased the linear density of dendritic spines without changing their length and width; conversely, knockdown experiments using RNAi caused a decrease in spine density, indicating FRMPD4 positively regulates dendritic spine density but not morphology. The decreased level of FRMPD4 also resulted in reduced levels of excitatory synaptic transmission, suggesting that FRMPD4 is required for maintenance of excitatory synaptic transmission.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A15565 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
FRMPD4 antibody can be used for detection of FRMPD4 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of FRMPD4 in SK-N-SH cell lysate with FRMPD4 antibody at (A) 1 and (B) 2 μg/mL.
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Immunohistochemistry of FRMPD4 in human brain tissue with FRMPD4 antibody at 5 μg/mL.
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Immunofluorescence of FRMPD4 in human brain tissue with FRMPD4 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For FRMPD4 (Source: Uniprot.org, NCBI)
Gene Name
FRMPD4
Full Name
FERM and PDZ domain-containing protein 4
Weight
144,379 MW
Alternative Names
FERM and PDZ domain-containing protein 4, PDZ domain-containing protein 10, PSD-95-interacting regulator of spine morphogenesis, Preso, KIAA0316, PDZD10, PDZK10 FRMPD4 MRX104, PDZD10, PDZK10 FERM and PDZ domain containing 4 FERM and PDZ domain-containing protein 4|PDZ domain-containing protein 10|PSD-95-interacting FERM and PDZ domain protein|PSD-95-interacting regulator of spine morphogenesis|Preso
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on FRMPD4, check out the FRMPD4 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for FRMPD4: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-FRMPD4 TMEM94 Antibody (A15565)
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