Anti-Forkhead box protein N4 FOXN4 Antibody

Product Name

Anti-Forkhead box protein N4 FOXN4 Antibody

View all Foxn4 Antibodies

SKU/Catalog Number

A10684

Size

100 µl

Form

Liquid

Description

Boster Bio Anti-Forkhead box protein N4 FOXN4 Antibody (Catalog # A10684). Tested in WB applications. This antibody reacts with Human.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Forkhead box protein N4 FOXN4 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A10684)

Host

Rabbit

Contents

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from internal of human FOXN4.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A10684 is reactive to FOXN4 in Human

Reconstitution

Calculated molecular weight

55215 MW

Background of Foxn4

Transcription factor essential for neural and some non-neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates through activating DLL4-NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the atrioventricular canal and is indirectly required for patterning the distal airway during lung development By similarity.

Scherer S.E., Nature 440:346-351(2006).
Danilova N., Brain Res. Dev. Brain Res. 153:115-119(2004).
Ota T., Nat. Genet. 36:40-45(2004).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A10684 is guaranteed for WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blotting: 1:500~1:3000

Validation Images & Assay Conditions

Gene/Protein Information For FOXN4 (Source: Uniprot.org, NCBI)

Alternative Names

Forkhead box protein N4;FOXN4; Foxn4|forkhead box N4|forkhead box protein N4

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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