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Product Info Summary
| SKU: | M04574 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Mouse |
| Application: | Flow Cytometry, IP, ICC, WB |
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Product info
Product Name
Anti-FOLR2 Purified Monoclonal Antibody
SKU/Catalog Number
M04574
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-FOLR2 Purified Monoclonal Antibody (Catalog# M04574). Tested in Flow Cytometry, IP, WB, ICC application(s). This antibody reacts with Human.
Storage & Handling
Store at 2-8°C. Do not freeze.
Cite This Product
Anti-FOLR2 Purified Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M04574)
Host
Mouse
Contents
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Clonality
Monoclonal
Clone Number
EM-35
Isotype
Mouse IgG1
Immunogen
BW5147alpha,beta- cells. The mouse monoclonal antibody EM-35 recognizes an extracellular epitope on FOLR2, a 30-40 kDa cell surface protein serving as a receptor for folic acid.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
This antibody does not cross-react with Thy-1.1 alloantigen.
Reactive Species
M04574 is reactive to FOLR2 in Human
Reconstitution
Observed Molecular Weight
42 kDa
Calculated molecular weight
29280 MW
Background of FOLR2
FOLR2 (folate receptor beta) is a cell surface protein that was originally thought to be specific for placenta, but it can be also expressed in other tissues, including hematopoietic cells. Its expression is increased in malignant tissues. FOLR2 may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. FOLR2 is a marker for macrophages generated in the presence of M-CSF (M2), including M2-like tumor-associated macrophages, which exert potent immunosuppressive functions within the tumor environment, but not GM-CSF (M1), and whose expression correlates with increased folate uptake ability.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
M04574 is guaranteed for Flow Cytometry, IP, ICC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Western blotting: Non-reducing conditions.
Flow cytometry: 1-4 µg/ml
Validation Images & Assay Conditions
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Figure 1. Western blotting validation for Anti-FOLR2 Purified Monoclonal Antibody M04574
Western blotting analysis of FOLR2 in THP1 cells (A) and FOLR2-transfected THP1 cells (B) using anti-FOLR2 (EM-35) purified.Electrophoresis was performed on a SDS-PAGE gel. To determine SDS-PAGE gel concentration
Protein Target Info & Infographic
Gene/Protein Information For FOLR2 (Source: Uniprot.org, NCBI)
Gene Name
FOLR2
Full Name
Folate receptor beta
Weight
29280 MW
Superfamily
folate receptor family
Alternative Names
Folate receptor beta, FBP, FR-P3, FR-BETA, BETA-HFR, FBP/PL-1 FOLR2 BETA-HFR, FBP, FBP/PL-1, FOLR1, FR-BETA, FR-P3, FRbeta folate receptor beta folate receptor beta|folate receptor 2 (fetal)|folate receptor alpha|folate receptor, fetal/placental|folate-binding protein, fetal/placental|placental folate-binding protein
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on FOLR2, check out the FOLR2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for FOLR2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-FOLR2 Purified Monoclonal Antibody (M04574)
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