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Product Info Summary
| SKU: | PA2143 |
|---|---|
| Size: | 100 μg/vial |
| Reactive Species: | Human, Rat |
| Host: | Rabbit |
| Application: | IHC, ICC, WB |
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Product info
Product Name
Anti-FGFR3 Antibody
SKU/Catalog Number
PA2143
Size
100 μg/vial
Form
Lyophilized
Description
Boster Bio Anti-FGFR3 Antibody catalog # PA2143. Tested in IHC, ICC, WB applications. This antibody reacts with Human, Rat.
Storage & Handling
Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-FGFR3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA2143)
Host
Rabbit
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Clonality
Polyclonal
Isotype
Rabbit IgG
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human FGFR3, different from the related rat sequence by two amino acids, and from the related mouse sequence by three amino acids.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross-reactivity with other proteins
Reactive Species
PA2143 is reactive to FGFR3 in Human, Rat
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Observed Molecular Weight
49 kDa
Calculated molecular weight
87710 MW
Background of FGFR3
Fibroblast growth factor receptor 3, also known as CD333, is a protein that in humans is encoded by the FGFR3 gene. This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. The FGFR3 gene is mapped to the HD region on chromosome 4p16.3. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
PA2143 is guaranteed for IHC, ICC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Immunocytochemistry , 0.5-1μg/ml, Human, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Rat, By Heat
Western blot, 0.1-0.5μg/ml, Human, Rat
Positive Control
WB: U87 Cell, SGC Cell,
IHC: Human Intestinal Cancer Tissue, Rat Lung Tissue
Validation Images & Assay Conditions
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Anti-FGFR3 antibody, PA2143, Western blotting
Lane 1: U87 Cell Lysate
Lane 2: SGC Cell Lysate
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Anti-FGFR3 antibody, PA2143, IHC(P)
IHC(P): Human Intestinal Cancer Tissue
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Anti-FGFR3 antibody, PA2143, IHC(P)
IHC(P): Rat Lung Tissue
Protein Target Info & Infographic
Gene/Protein Information For FGFR3 (Source: Uniprot.org, NCBI)
Gene Name
FGFR3
Full Name
Fibroblast growth factor receptor 3
Weight
87710 MW
Superfamily
protein kinase superfamily
Alternative Names
Fibroblast growth factor receptor 3;FGFR-3;2.7.10.1;CD333;FGFR3;JTK4; FGFR3 ACH, CD333, CEK2, HSFGFR3EX, JTK4 fibroblast growth factor receptor 3 fibroblast growth factor receptor 3|FGFR-3|fibroblast growth factor receptor 3 variant 4|fibroblast growth factor receptor 3-S|hydroxyaryl-protein kinase|tyrosine kinase JTK4
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on FGFR3, check out the FGFR3 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for FGFR3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-FGFR3 Antibody (PA2143)
Hello CJ!
PA2143 has been cited in 1 publications:
*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.
Co-expression of fibroblast growth factor receptor 3 with mutant p53, and its association with worse outcome in oropharyngeal squamous cell carcinoma
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