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FGFR3 Antibodies
AND FGFR3 ELISA kits, FGFR3 Proteins
Many biological assays use antibodies to detect FGFR3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FGFR3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FGFR3 antibodies...
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FGFR3 Infographic by Boster Bio
All FGFR3 Products
Product
Figures
Specificity
Applications
Price
Anti-FGFR3 Rabbit Monoclonal Antibody
1 Citations 2 Q&As
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00200-1
100 μl
Cat # M00200-1
100 μl
Human, Mouse, Rat
ELISA
$480
Cat # EKC1214
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1214
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
IF, IHC, WB
$523
Cat # M00200-2
100 µl
Cat # M00200-2
100 µl
Human, Mouse
Flow Cytometry, IP, IF, ICC, WB
$370
Cat # P00200
100 μl/vial
Cat # P00200
100 μl/vial
FGFR3 Overview
Facts about Fibroblast growth factor receptor 3.
Fibroblast growth factor receptor 3 (FGFR3)
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an important role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is necessary for normal skeleton development.
Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation.
Gene Information
| Human | |
|---|---|
| Gene Name: | FGFR3 |
| Uniprot: | P22607 |
| Entrez: | 2261 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
CD333; CEK; EC 2.7.10; FGF R3; FGFR3; fibroblast growth factor receptor 3; HSFGFR3EX; JTK4; JTK4thanatophoric dwarfism
Molecular Weight
Mass (kDA):
87.71 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4p16.3 |
| Sequence: | 4; NC_000004.12 (1793293..1808872) |
Tissue Specificity
Expressed in brain, kidney and testis. Very low or no expression in spleen, heart, and muscle. In 20- to 22- week old fetuses it is expressed at high level in kidney, lung, small intestine and brain, and to a lower degree in spleen, liver, and muscle. Isoform 2 is detected in epithelial cells. Isoform 1 is not detected in epithelial cells. Isoform 1 and isoform 2 are detected in fibroblastic cells.
Subcellular Localizations
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Endoplasmic reticulum. The activated receptor is rapidly internalized and degraded. Detected in intracellular vesicles after internalization of the autophosphorylated receptor.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.; [Isoform 4]: Cell membrane; Single-pass type I membrane protein.
Diseases
- Neoplasms
- Malignant Neoplasms
- Achondroplasia
- Dysplasia
- Carcinoma
- Dwarfism
- Multiple Myeloma
- Bladder Neoplasm
- Craniosynostosis
- Malignant Neoplasm Of Urinary Bladder
- Thanatophoric Dysplasia
- Hypochondroplasia (disorder)
Interacting Proteins
- FGF1
- HSP90AB1
Pathways
- Pathogenesis
- Cell Proliferation
- Ossification
- Chondrocyte Proliferation
- Localization
- Cell Growth
- Endochondral Ossification
- Cell Cycle
- Chondrocyte Differentiation
- Bone Development
- Cell Differentiation
- Angiogenesis
- Regeneration
PTMs
- Phosphorylation
- Methylation
- Glycosylation
- Cleavage
- Ubiquitination
Research Areas
- Angiogenesis
- Cancer
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FGFR3
bosterbio.com/bosterbio-gene-info-cards/FGFR3
References
PMID: 1847508 by Keegan K., et al. Isolation of an additional member of the fibroblast growth factor receptor family, FGFR-3.
PMID: 11703096 by Terada M., et al. Fibroblast growth factor receptor 3 lacking the Ig IIIb and transmembrane domains secreted from human squamous cell carcinoma DJM- 1 binds to FGFs.
5 Publications of Boster FGFR3 Antibodies & ELISA Kits
- PubMed ID: 10.1371/journal.pone.0247498, Co-expression of fibroblast growth factor receptor 3 with mutant p53, and its as...
- PubMed ID: 10.1097/WNR.0000000000001591, Expression of fibroblast growth factor 9 and its receptors in the dentate gyrus ...
- PubMed ID: 10.1016/j.etap.2019.103275, Fluoride regulates the expression of extracellular matrix HSPG and related signa...
- PubMed ID: 33626078, Nannapaneni S,Griffith CC,Magliocca KR,Chen W,Lyu X,Chen Z,Wang D,Wang X,Shin DM...
- PubMed ID: 31731208, Gao Y,Gui F,Li D,Zhang R,Sun Q,Guo X.Fluoride regulates the expression of extrac...
*More publications can be found for each product on its corresponding product page