Data

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Key=store_id
Key=entity_id, value=1446
Key=attribute_set_id, value=4
Key=type_id, value=simple
Key=sku, value=PA1882
Key=has_options, value=1
Key=required_options, value=1
Key=created_at, value=2014-05-08 15:19:07
Key=updated_at, value=2024-10-19 05:03:09
Key=mst_search_weight, value=0
Key=status, value=Enabled
Key=name, value=Anti-Tyrosine-protein kinase Fer FER Antibody Picoband®
Key=cj_search_index
Key=publication_count, value=0
Key=qty_in_warehouses
Key=is_recurring, value=No
Key=visibility, value=Catalog, Search
Key=tax_class_id, value=Taxable Goods
Key=featured, value=No
Key=featured_image, value=Yes
Key=fb_product, value=
Key=custom_product_page, value=No
Key=free_shipping, value=No
Key=template, value=antibodies
Key=host, value=Rabbit
Key=quantity_and_stock_status
Key=googleshopping_exclude, value=No
Key=yoast_keyword_score, value=-1575
Key=yoast_content_score, value=30
Key=badge, value=free-antibody-validation
Key=price, value=370.0000
Key=weight, value=1.0000
Key=meta_title, value=FER/Tyrosine-protein kinase Fer Antibody
Key=meta_description, value=Boster Bio Anti-Tyrosine-protein kinase Fer FER Antibody catalog # PA1882. Tested in IHC, WB applications. This antibody reacts with Human, Rat. Supplied as 100μg/vial in Lyophilized form antibody.
Key=image, value=/p/a/pa1882-2.jpg
Key=small_image, value=/p/a/pa1882-2.jpg
Key=thumbnail, value=/p/a/pa1882-2.jpg
Key=url_key, value=anti-fer-antibody-pa1882-boster
Key=url_path, value=anti-fer-antibody-pa1882-boster
Key=options_container, value=Product Info Column
Key=image_label, value=Anti-FER antibody, PA1882, IHC(P)
IHC(P): Human Intestinal Cancer Tissue
Key=small_image_label, value=Anti-FER antibody, PA1882, IHC(P)
IHC(P): Human Intestinal Cancer Tissue
Key=thumbnail_label, value=Anti-FER antibody, PA1882, IHC(P)
IHC(P): Human Intestinal Cancer Tissue
Key=msrp_display_actual_price_type, value=
Key=gift_message_available, value=No
Key=size, value=100 μg/vial
Key=protein_name, value=Tyrosine-protein kinase Fer
Key=gene_full_name, value=Tyrosine-protein kinase Fer
Key=uniprot_id, value=P16591
Key=reconstitution, value=Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Key=sensitivity
Key=applications, value=IHC, WB
Key=reactivity, value=Human, Rat
Key=form, value=Lyophilized
Key=concentration, value=Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Key=cross_reactivity, value=No cross-reactivity with other proteins
Key=recommended_detection_systems, value=Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
Key=predicted_reactivity
Key=source_company, value=Boster PA1882
Key=isotype, value=Rabbit IgG
Key=molecular_weight, value=94638 MW
Key=sample_size_available, value=30ug for $99, contact us for details
Key=related_product_skus, value=B0001-5,AR1156,AR0146
Key=product_category, value=Primary Antibodies
Key=research_category, value=Cell Biology, Cell Cycle, Kinases/Phosphatases, Protein Phosphorylation, Signal Transduction, Tyrosine Kinases
Key=clonality, value=Polyclonal
Key=swatch_image, value=/e/k/ek0464.png
Key=rating_value, value=96.3
Key=review_count, value=5
Key=phospho_site
Key=mp_exclude_sitemap, value=No
Key=yoast_focus_keyword, value=CD68 antibody
Key=yoast_facebook_image, value=/p/a/pa1787-2-hexa-primary-antibodies-wb-testing-1_1.jpg
Key=yoast_twitter_image, value=/p/a/pa1787-2-hexa-primary-antibodies-wb-testing-1_1.jpg
Key=cj_related_products, value=Cholesterol Esterification:PB9657|EKC2561|PA2281^Coronary Artery Disease:A13444^Iron Deficiency:PROTQ6UWR7
Key=description, value=Boster Bio Anti-Tyrosine-protein kinase Fer FER Antibody catalog # PA1882. Tested in IHC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Key=short_description, value=Boster Bio Anti-Tyrosine-protein kinase Fer FER Antibody catalog # PA1882. Tested in IHC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Key=meta_keyword, value=Anti-Tyrosine-protein kinase Fer FER Antibody
Key=contents, value=Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Key=background, value=FER (FPS/FES-Related tyrosine kinase) also known as TYK3, is an enzyme that in humans is encoded by the FER gene. Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. By in situ hybridization, Morris et al. (1990) concluded that the FER gene is located at 5q21-q22. Treatment of cells with JMP resulted in the release of FER from the cadherin complex and its accumulation in the integrin complex. The accumulation of FER in the integrin complex and the inhibitory effects of JMP could be reversed with a peptide that mimics the first coiled-coil domain of FER. The results suggested that FER mediates crosstalk between CDH2 and ITGB1. In Fer mutant mice, leukocyte emigration was exaggerated in response to LPS without altering vascular permeability, suggesting that FER has a role in regulating innate immunity.
Key=gene_name, value=FER
Key=synonyms, value=Tyrosine-protein kinase Fer;2.7.10.2;Feline encephalitis virus-related kinase FER;Fujinami poultry sarcoma/Feline sarcoma-related protein Fer;Proto-oncogene c-Fer;Tyrosine kinase 3;p94-Fer;FER;TYK3;
Key=application_details, value=Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Rat, By Heat
Western blot, 0.1-0.5μg/ml, Human, Rat

Key=subcellular_localization, value= Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cell junction. Membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, cell cortex. Associated with the chromatin. Detected on microtubules in polarized and motile vascular endothelial cells. Colocalizes with F-actin at the cell cortex. Colocalizes with PECAM1 and CTNND1 at nascent cell- cell contacts.
Key=sequence_similarities, value=Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
Key=tissue_specificity, value= Isoform 1 is detected in normal colon and in fibroblasts (at protein level). Isoform 3 is detected in normal testis, in colon carcinoma-derived metastases in lung, liver and ovary, and in colon carcinoma and hepato carcinoma cell lines (at protein level). Isoform 3 is not detected in normal colon or in normal fibroblasts (at protein level). Widely expressed. .
Key=application_notes, value=WB: The detection limit for FER is approximately 5ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.
Key=competitor_equivalent_skus, value=sc 30706|sc 14310|sc 30707|sc 28771|sc 390484|sc 81461|sc 81708|sc 81272
Key=immunogen, value=A synthetic peptide corresponding to a sequence in the middle region of human FER, different from the related rat and mouse sequences by two amino acids.
Key=purification, value=Immunogen affinity purified.
Key=storage, value=Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Key=custom_attribute_1, value=95 kDa
Key=custom_attribute_2, value=WB: HELA Whole Cell, Rat Testis Tissue, Rat Ovary Tissue
IHC: Human Intestinal Cancer Tissue, Rat Intestine Tissue
Key=custom_attribute_3, value=BA3846
Key=protein_function, value= Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus. .
Key=options
Key=media_gallery
Key=extension_attributes
Key=tier_price
Key=tier_price_changed
Key=category_ids
Key=is_salable
Key=website_ids
Key=request_path
Key=rating_summary
Key=_cache_instance_store_filter
Key=media_gallery_images