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Product Info Summary
| SKU: | A02387-1 |
|---|---|
| Size: | 80 µl |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | Flow Cytometry, IF, IHC-P, WB |
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Product info
Product Name
Anti-FANCC Antibody (C-term)
SKU/Catalog Number
A02387-1
Size
80 µl
Description
Boster Bio Anti-FANCC Antibody (C-term) (Catalog # A02387-1). Tested in WB, IF, Flow Cytometry, IHC-P application(s). This antibody reacts with Human.
Storage & Handling
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Cite This Product
Anti-FANCC Antibody (C-term) (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02387-1)
Host
Rabbit
Contents
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Clonality
Polyclonal
Isotype
Rabbit IgG
Immunogen
This FANCC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 527-555 amino acids from the C-terminal region of human FANCC.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A02387-1 is reactive to FANCC in Human
Applications
A02387-1 is guaranteed for Flow Cytometry, IF, IHC-P, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
63429 Da
Background of FANCC
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This protein is for complementation group C.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
IF: 1:25
WB: 1:1000
IHC-P: 1:50-1:100
FC: 1:10-1:50
Validation Images & Assay Conditions
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Immunofluorescent analysis of U251 cells, using FANCC Antibody (C-term). A02387-1 was diluted at 1:25 dilution. Alexa Fluor 488-conjugated goat anti-rabbit lgG at 1:400 dilution was used as the secondary antibody (green). DAPI was used to stain the cell nuclear (blue).
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Western blot analysis of lysates from HepG2,HL-60 cell line (from left to right),using FANCC Antibody (C-term).A02387-1 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug per lane.
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FANCC Antibody (C-term) IHC analysis in formalin fixed and paraffin embedded testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the FANCC Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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FANCC Antibody (C-term) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Protein Target Info & Infographic
Gene/Protein Information For FANCC (Source: Uniprot.org, NCBI)
Gene Name
FANCC
Full Name
Fanconi anemia group C protein
Weight
63429 Da
Alternative Names
FA Complementation Group C; FA3; FACC; FACCProtein FACC; FACFanconi anemia group C protein; FANCC; Fanconi anemia, complementation group C; FLJ14675 FANCC FA3, FAC, FACC FA complementation group C Fanconi anemia group C protein|Fanconi anemia complementation group C
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on FANCC, check out the FANCC Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for FANCC: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-FANCC Antibody (C-term) (A02387-1)
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