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FANCC Antibodies
AND FANCC ELISA kits, FANCC Proteins
Many biological assays use antibodies to detect FANCC, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FANCC in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FANCC antibodies...
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FANCC Overview
Facts about Fanconi anemia group C protein.
Fanconi anemia group C protein (FANCC)
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link fix and in the maintenance of normal chromosome stability.
Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. .
Gene Information
| Human | |
|---|---|
| Gene Name: | FANCC |
| Uniprot: | Q00597 |
| Entrez: | 2176 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
FA Complementation Group C; FA3; FACC; FACCProtein FACC; FACFanconi anemia group C protein; FANCC; Fanconi anemia, complementation group C; FLJ14675
Molecular Weight
Mass (kDA):
63.429 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9q22.32 |
| Sequence: | 9; NC_000009.12 (95099054..95317730, complement) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
Nucleus. Cytoplasm. The major form is nuclear. The minor form is cytoplasmic.
Diseases
- Anemia
- Fanconi Anemia
- Malignant Neoplasms
- Pancytopenia
- Congenital Abnormality
- Neoplasms
- Leukemia
- Hereditary Diseases
- Chromosome Breakage
- Myeloid Leukemia
- Malignant Neoplasm Of Breast
- Aplastic Anemia
- Leukemia, Myelocytic, Acute
Interacting Proteins
- HSP90B1
Pathways
- Hypersensitivity
- Dna Repair
- Cell Cycle
- Localization
- Pathogenesis
- Cell Death
- Methylation
- Chromosome Breakage
- G2 Phase
- Dna Replication
- Programmed Cell Death
- Cell Cycle Arrest
- Mitosis
PTMs
- Phosphorylation
- Methylation
- Ubiquitination
Research Areas
- Breast Cancer
- Cancer
- DNA Repair
- Genes Sensitive to DNA Damaging Agents
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FANCC
bosterbio.com/bosterbio-gene-info-cards/FANCC
References
PMID: 1574115 by Strathdee C.A., et al. Cloning of cDNAs for Fanconi's anaemia by functional complementation.
PMID: 8490620 by Gibson R.A., et al. Characterisation of the exon structure of the Fanconi anaemia group C gene by vectorette PCR.