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Product Info Summary
| SKU: | PA2031 |
|---|---|
| Size: | 100 μg/vial |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | IHC, WB |
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Product info
Product Name
Anti-integrin beta 4 binding protein/EIF6 Antibody
View all integrin beta 4 binding protein Antibodies
SKU/Catalog Number
PA2031
Size
100 μg/vial
Form
Lyophilized
Description
Boster Bio Anti-integrin beta 4 binding protein/EIF6 Antibody catalog # PA2031. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-integrin beta 4 binding protein/EIF6 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA2031)
Host
Rabbit
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Clonality
Polyclonal
Isotype
Rabbit IgG
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human EIF6, different from the related rat and mouse sequences by one amino acid.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross-reactivity with other proteins
Reactive Species
PA2031 is reactive to EIF6 in Human, Mouse, Rat
Applications
PA2031 is guaranteed for IHC, WB Boster Guarantee
Observed Molecular Weight
115 kDa
Calculated molecular weight
26599 MW
Background of integrin beta 4 binding protein
EIF6 (Eukaryotic Translation Initiation Factor 6), also called EIF3A or ITGB4BP, is a human gene. By fluorescence in situ hybridization, Sanvito et al. (1998) mapped the ITGB4BP gene to 20q11.2. Ceci et al. (2003) demonstrated that the ribosomal 60S subunit is activated by release of EIF6. In the cytoplasm, EIF6 is bound to free 60S but not to 80S subunits. Furthermore, EIF6 interacts in the cytoplasm with RACK1, a receptor for activated protein kinase C. Gandin et al. (2008) demonstrated that mammalian eIF6 is required for efficient initiation of translation in vivo. Eif6-null mouse embryos were lethal at preimplantation. Heterozygous mice had 50% reduction of eIF6 levels in all tissues, and showed reduced mass of hepatic and adipose tissues due to a lower number of cells and to impaired G1/S cell cycle progression.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Assay dilution & Images
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Mouse, Rat, By Heat
Immunohistochemistry (Frozen Section), 0.5-1μg/ml, Human, Mouse, Rat
Western blot, 0.1-0.5μg/ml, Human, Mouse, Rat
Validation Images & Assay Conditions
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Anti-EIF6 antibody, PA2031, Western blotting
Lane 1: Rat Liver Tissue Lysate
Lane 2: Rat Kidney Tissue Lysate
Lane 3: COLO320 Cell Lysate
Lane 4: SW620 Cell Lysate
Lane 5: HELA Cell Lysate
Lane 6: 293T Cell Lysate
Lane 7: HEPA Cell Lysate
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Anti-EIF6 antibody, PA2031, IHC(P)
IHC(P): Human Intestinal Cancer Tissue
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Anti-EIF6 antibody, PA2031, IHC(F)
IHC(F): Human Placenta Tissue
Protein Target Info & Infographic
Gene/Protein Information For EIF6 (Source: Uniprot.org, NCBI)
Gene Name
EIF6
Full Name
Eukaryotic translation initiation factor 6
Weight
26599 MW
Superfamily
eIF-6 family
Alternative Names
B(2)GCN homolog; b(2)gcn; B4 integrin interactor; CAB; EIF3Ap27(BBP); eIF-6; eukaryotic translation initiation factor 3A; eukaryotic translation initiation factor 6; ITGB4BPintegrin beta 4 binding protein; p27 beta-4 integrin-binding protein; p27BBP EIF6 CAB, EIF3A, ITGB4BP, b(2)gcn, eIF-6, p27(BBP), p27BBP eukaryotic translation initiation factor 6 eukaryotic translation initiation factor 6|B4 integrin interactor|eukaryotic translation initiation factor 3A|p27 beta-4 integrin-binding protein
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on EIF6, check out the EIF6 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for EIF6: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-integrin beta 4 binding protein/EIF6 Antibody (PA2031)
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