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Product Info Summary
| SKU: | A05136-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, ICC, WB |
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Product info
Product Name
Anti-DcR2 TNFRSF10D Antibody
View all TRAILR4/TNFRSF10D/DcR2 Antibodies
SKU/Catalog Number
A05136-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-DcR2 TNFRSF10D Antibody (Catalog # A05136-1). Tested in ELISA, WB, ICC, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
DcR2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-DcR2 TNFRSF10D Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A05136-1)
Host
Rabbit
Contents
DcR2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
DcR2 antibody was raised against a 15 amino acid peptide near the center of human DcR2. The immunogen is located within amino acids 230 - 280 of DcR2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least three isoforms are known to exist; this antibody will detect all three isoforms. Despite its predicted molecular weight, LNPEP often migrates at 165kD in SDS-PAGE.
Reactive Species
A05136-1 is reactive to TNFRSF10D in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
41823 MW
Background of TRAILR4/TNFRSF10D/DcR2
Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor. Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL-R4, or TRUNDD. DcR2 has an extracellular TRAIL-binding domain but lacks intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuated TRAIL-induced apoptosis.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A05136-1 is guaranteed for ELISA, IF, IHC-P, ICC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
DcR2 antibody can be used for detection of DcR2 expression by Western blot at 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 10 μg/mL and Immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples; Immunocytochemistry in human samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of DcR2 in HeLa whole cell lysate with DcR2 antibody at 1 μg/mL.
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Immunocytochemistry staining of HeLa cells using DcR2 antibody at 10μg/mL.
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Immunohistochemistry of DcR2 in mouse kidney node tissue with DcR2 antibody at 2.5 μg/ml.
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Immunofluorescence of DcR2 in mouse kidney tissue withDcR2 antibody at 20 μg/ml.
Green: DcR2 Antibody (A05136-1)
Blue: DAPI staining
Protein Target Info & Infographic
Gene/Protein Information For TNFRSF10D (Source: Uniprot.org, NCBI)
Gene Name
TNFRSF10D
Full Name
Tumor necrosis factor receptor superfamily member 10D
Weight
41823 MW
Alternative Names
DCR2, CD264, TRUNDD, TRAILR4, TRAIL-R4, DCR2, UNQ251/PRO288, Tumor necrosis factor receptor superfamily member 10D, Decoy receptor 2, DcR2 TNFRSF10D CD264, DCR2, TRAIL-R4, TRAILR4, TRUNDD TNF receptor superfamily member 10d tumor necrosis factor receptor superfamily member 10D|TNF receptor-related receptor for TRAIL|TNF-related apoptosis-inducing ligand receptor 4|TRAIL receptor 4|TRAIL receptor with a truncated death domain|decoy receptor 2|tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TNFRSF10D, check out the TNFRSF10D Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TNFRSF10D: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-DcR2 TNFRSF10D Antibody (A05136-1)
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