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Product Info Summary
| SKU: | A15882-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-DCLK3 Antibody
SKU/Catalog Number
A15882-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-DCLK3 Antibody (Catalog # A15882-1). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.
Storage & Handling
DCLK3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-DCLK3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A15882-1)
Host
Rabbit
Contents
DCLK3 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
DCLK3 antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of human DCLK3. The immunogen is located within the last 50 amino acids of DCLK3.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
SUSD1 Antibody is predicted to not cross-react with other SUSDfamiliy members.
Reactive Species
A15882-1 is reactive to DCLK3 in Human, Mouse
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
73814 MW
Background of DCLK3
DCLK3 is one of three doublecortin-like kinases similar to the Ca2+/calmodulin-dependent protein kinase (CaMK) family. DCLK3 mRNA, like that of the homologous DCLK1 and DCLK3, is highly expressed in adult brain, but only DCLK3 transcripts are present in liver and kidney, suggesting that DCLK3 may play other roles than in cortical development. The DCLK proteins are homologous to Doublecortin (DCX), a protein that is mutated in X-linked human lissencephaly. In mouse models where the DCX gene has been disrupted, DCLK1 expression increases slightly and appears to compensate for the loss of DCX, as mice mutant for both DCX and DCLK1 show a severe phenotype including perinatal lethality, disorganized neocortical layering, and profound hippocampal cytoarchitectural disorganization.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A15882-1 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
DCLK3 antibody can be used for detection of DCLK3 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in human and mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of DCLK3 in K562 cell lysate with DCLK3 antibody at (A) 1 and (B) 2 μg/mL.
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Immunofluorescence of DLCK3 in human brain tissue with DLCK3 antibody at 20 μg/mL.
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Immunohistochemistry of DCLK3 in mouse brain tissue with DCLK3 Antibody at 5 μg/mL.
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Immunofluorescence of DCLK3 in mouse brain tissue with DCLK3 Antibody at 20 μg/mL.
Green: DCLK3 antibody (A15882-1)
Red: Phylloidin staining
Blue: DAPI staining
Protein Target Info & Infographic
Gene/Protein Information For DCLK3 (Source: Uniprot.org, NCBI)
Gene Name
DCLK3
Full Name
Serine/threonine-protein kinase DCLK3
Weight
73814 MW
Superfamily
protein kinase superfamily
Alternative Names
CLR, DCK3, DCDC3C, DCAMKL3, KIAA1765, Doublecortin domain-containing protein 3C DCLK3 CLR, DCAMKL3, DCDC3C, DCK3 doublecortin like kinase 3 serine/threonine-protein kinase DCLK3|CLICK-I,II-related|doublecortin and CaM kinase-like 3|doublecortin domain-containing protein 3C|doublecortin-like and CAM kinase-like 3
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on DCLK3, check out the DCLK3 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for DCLK3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-DCLK3 Antibody (A15882-1)
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