Anti-Cytochrome P450 26A1 CYP26A1 Antibody

Product Name

Anti-Cytochrome P450 26A1 CYP26A1 Antibody

View all CYP26A1 Antibodies

SKU/Catalog Number

A03646

Size

100ul

Form

Liquid

Description

Boster Bio Anti-Cytochrome P450 26A1 CYP26A1 Antibody catalog # A03646. Tested in WB,IHC applications. This antibody reacts with Human,Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Cytochrome P450 26A1 CYP26A1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03646)

Host

Rabbit

Contents

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from human PAR-4

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A03646 is reactive to CYP26A1 in Human, Rat

Applications

A03646 is guaranteed for IHC, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

56199 MW

Background of CYP26A1

Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.

Hongzhe Li, J. Biol. Chem., Feb 2007; 282: 4943 - 4950.
Wuhan Xiao, Cancer Res., Aug 2003; 63: 4698 - 4704.
Thierry Virolle, J. Biol. Chem., Mar 2003; 278: 11802 - 11810.
Derek J. Richard, Genes & Dev., Feb 2001; 15: 328.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1:500-1:1,000
IHC: 1:50-1:200

Validation Images & Assay Conditions

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Figure 2. Immunohistochemistry validation of CYP26A1 using Anti-Cytochrome P450 26A1 CYP26A1 Antibody (A03646).

Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-CYP26A1 antibody. Counter stained with hematoxylin.
For more protocol information of IHC

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Figure 1. Western blotting validation for Anti-Cytochrome P450 26A1 CYP26A1 Antibody A03646

Western blot analysis of CYP26A1 on HepG2 cell lysate using anti-CYP26A1 antibody at 1/500 dilution.
Electrophoresis was performed on a SDS-PAGE gel. To determine SDS-PAGE gel concentration

Gene/Protein Information For CYP26A1 (Source: Uniprot.org, NCBI)

Alternative Names

CP26; CYP26Retinoic acid 4-hydroxylase; cytochrome P450 26A1; Cytochrome P450 retinoic acid-inactivating 1; cytochrome P450, family 26, subfamily A, polypeptide 1; cytochrome P450, subfamily XXVIA, polypeptide 1; Cytochrome P450RAI; EC 1.14; hP450RAI; P450, retinoic acid-inactivating, 1; P450RAI; P450RAI1Retinoic acid-metabolizing cytochrome CYP26A1 CP26, CYP26, P450RAI, P450RAI1 cytochrome P450 family 26 subfamily A member 1 cytochrome P450 26A1|P450, retinoic acid-inactivating, 1|cytochrome P450 retinoic acid-inactivating 1|cytochrome P450, family 26, subfamily A, polypeptide 1|cytochrome P450, subfamily XXVIA, polypeptide 1|cytochrome P450RAI|hP450RAI|retinoic acid 4-hydroxylase|retinoic acid-metabolizing cytochrome

For more info on CYP26A1, check out the CYP26A1 Infographic

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In this infographic, you will see the following information for CYP26A1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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