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Cytochrome P450 26A1 Antibodies
AND CYP26A1 ELISA kits, Cytochrome P450 26A1 Proteins
Many biological assays use antibodies to detect Cytochrome P450 26A1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cytochrome P450 26A1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cytochrome P450 26A1 antibodies...
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CYP26A1 Infographic by Boster Bio
All CYP26A1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA
$480
Cat # EKC1908
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1908
1 kit, containing one 96-well plate and all necessary reagents
CYP26A1 Overview
Facts about Cytochrome P450 26A1.
Cytochrome P450 26A1 (CYP26A1)
Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA.
Capable of both 4-hydroxylation and 18- hydroxylation. Responsible for generation of several hydroxylated forms of RA, such as 4-OH-RA, 4-oxo-RA and 18-OH-RA.
Gene Information
| Human | |
|---|---|
| Gene Name: | CYP26A1 |
| Uniprot: | O43174 |
| Entrez: | 1592 |
Family
| Belongs to: |
|---|
| cytochrome P450 family |
Alternative Names
CP26; CYP26Retinoic acid 4-hydroxylase; cytochrome P450 26A1; Cytochrome P450 retinoic acid-inactivating 1; cytochrome P450, family 26, subfamily A, polypeptide 1; cytochrome P450, subfamily XXVIA, polypeptide 1; Cytochrome P450RAI; EC 1.14; hP450RAI; P450, retinoic acid-inactivating, 1; P450RAI; P450RAI1Retinoic acid-metabolizing cytochrome
Molecular Weight
Mass (kDA):
56.199 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q23.33 |
| Sequence: | 10; NC_000010.11 (93073475..93077885) |
Tissue Specificity
Highest levels in adult liver, heart, pituitary gland, adrenal gland, placenta and regions of the brain.
Subcellular Localizations
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Diseases
- Malignant Neoplasms
- Carcinoma
- Neoplasms
- Vitamin A Deficiency
- Refractory Anemia With Ringed Sideroblasts
- Carcinogenesis
- Leukemia
- Spina Bifida
- Inflammation
- Teratogenic Effect
- Nervousness
- Acute Promyelocytic Leukemia
- Endometrial Polyp
Pathways
- Cell Differentiation
- Cell Proliferation
- Somitogenesis
- Pathogenesis
- Segmentation
- Gastrulation
- Localization
- Eye Development
- Methylation
- Dna Methylation
- Transport
- Cell Cycle
- Cell Death
PTMs
- Oxidation
- Methylation
- Acetylation
Research Areas
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CYP26A1
bosterbio.com/bosterbio-gene-info-cards/CYP26A1
References
PMID: 9228017 by White J.A., et al. cDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450.
PMID: 9716180 by Sonneveld E., et al. Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific for all-trans-RA and can be induced through RA receptors in human breast and colon carcinoma cells.