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Product Info Summary
| SKU: | M00877 |
|---|---|
| Size: | 100ug/vial |
| Reactive Species: | Human |
| Host: | Mouse |
| Application: | ELISA, IHC |
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Product info
Product Name
Anti-CDX2 (GI Epithelial Marker) Monoclonal Antibody
SKU/Catalog Number
M00877
Size
100ug/vial
Form
Liquid
Description
Boster Bio Anti-CDX2 (GI Epithelial Marker) Monoclonal Antibody (Catalog # M00877). Tested in ELISA, IHC applications. This antibody reacts with Human.
Storage & Handling
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Cite This Product
Anti-CDX2 (GI Epithelial Marker) Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M00877)
Host
Mouse
Contents
Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Clonality
Monoclonal
Clone Number
Clone: CDX2/1690
Isotype
IgG2a, kappa
Immunogen
Recombinant fragment (around aa150-249) of human CDX2 protein (exact sequence is proprietary)
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Does not cross-react with primate, avian or amphibian GR.
Reactive Species
M00877 is reactive to CDX2 in Human
Reconstitution
Reconstitute with distilled water.
Observed Molecular Weight
68 kDa
Calculated molecular weight
33520 MW
Background of CDX2
The intestine-specific transcription factors CDX1 and CDX2 are important for directing intestinal development, differentiation, proliferation and maintenance of the intestinal phenotype. CDX2 protein expression has been seen in GI carcinomas. Anti-CDX2 has been useful to establish GI origin of metastatic adenocarcinomas and carcinoidsand is especially useful to distinguish metastatic colorectal adenocarcinoma from lung adenocarcinoma.However, mucinous carcinomas of the ovary also express CDX2 protein. It limits the usefulness of this marker in the distinction of metastatic colorectal adenocarcinoma from mucinous carcinoma of the ovary.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
M00877 is guaranteed for ELISA, IHC Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
ELISA (Use Ab at 2-4ug/ml for coating) (Order Ab without BSA)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT) (Staining of formalin-fixed tissues is enhanced by heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0 for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.
Validation Images & Assay Conditions
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Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with Anti-CDX2 Mouse Monoclonal Antibody (CDX2/1690).
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Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with Anti-CDX2 Mouse Monoclonal Antibody (CDX2/1690).
Protein Target Info & Infographic
Gene/Protein Information For CDX2 (Source: Uniprot.org, NCBI)
Gene Name
CDX2
Full Name
Homeobox protein CDX-2
Weight
33520 MW
Superfamily
Caudal homeobox family
Alternative Names
Homeobox protein CDX-2;CDX-3;Caudal-type homeobox protein 2;CDX2;CDX3; CDX2 CDX-3/AS, CDX3, CDX2 caudal type homeobox 2 homeobox protein CDX-2|caudal type homeobox transcription factor 2|caudal-type homeobox protein 2|homeobox protein miniCDX2
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on CDX2, check out the CDX2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for CDX2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-CDX2 (GI Epithelial Marker) Monoclonal Antibody (M00877)
Hello CJ!
M00877 has been cited in 1 publications:
*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.
Overexpression of caudal-related homeobox transcription factor 2 inhibits the growth of transplanted colorectal tumors in nude mice
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