Product Info Summary
SKU: | A07686-2 |
---|---|
Size: | 0.1 mg |
Reactive Species: | Human |
Host: | Rabbit |
Application: | ELISA, IHC-P |
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Product info
Product Name
Anti-CARMA3 CARD10 Antibody
SKU/Catalog Number
A07686-2
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-CARMA3 CARD10 Antibody (Catalog # A07686-2). Tested in ELISA, IHC-P applications. This antibody reacts with Human.
Storage & Handling
CARMA3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-CARMA3 CARD10 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A07686-2)
Host
Rabbit
Contents
CARMA3 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
CARMA3 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human CARMA3. The immunogen is located within the first 50 amino acids of CARMA3.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
CARMA3 antibody is human specific. At least three isoforms of CARMA3 are known to exist; this antibody will only detect isoform 1. CARMA3 antibody is predicted not to cross-react with other CARMA proteins.
Reactive Species
A07686-2 is reactive to CARD10 in Human
Applications
A07686-2 is guaranteed for ELISA, IHC-P Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
115931 MW
Background of CARD10
CARMA proteins belong to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. As with CARMA1, the CARD domain of CARMA3 has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-κB activation. When expressed in cells, this protein binds to BCL10 and activates NF-κB Recent experiments have shown that CARMA3 is required for EGF-induced NF-κB activation and contributes to tumor growth in vivo, suggesting that CARMA3 may serve as a new therapeutic target for the treatment of EGFR-driven tumors.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
CARMA3 antibody can be used for detection of CARMA3 by immunohistochemistry at 5 μg/mL.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
![a07686 2 anti carma3 card10 antibody wb testing 1 a07686 2 anti carma3 card10 antibody wb testing 1](https://www.bosterbio.com/media/catalog/product/a/0/a07686-2-anti-carma3-card10-antibody-wb-testing-1.jpg)
Click image to see more details
Immunohistochemistry of CARMA3 in human kidney tissue with CARMA3 antibody at 5 μg/ml
Protein Target Info & Infographic
Gene/Protein Information For CARD10 (Source: Uniprot.org, NCBI)
Gene Name
CARD10
Full Name
Caspase recruitment domain-containing protein 10
Weight
115931 MW
Alternative Names
CARD-containing MAGUK 3 protein; CARD-containing MAGUK protein 3; Carma 3; CARMA3BIMP1Bcl10 binding protein and activator of NFKB; caspase recruitment domain family, member 10; caspase recruitment domain-containing protein 10; MGC142219 CARD10 BIMP1, CARMA3 caspase recruitment domain family member 10 caspase recruitment domain-containing protein 10|Bcl10 binding protein and activator of NFKB|CARD-containing MAGUK 3 protein|CARD-containing MAGUK protein 3|carma 3
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on CARD10, check out the CARD10 Infographic
![CARD10 infographic](/media/images/gene-infographic-example.jpg)
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for CARD10: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-CARMA3 CARD10 Antibody (A07686-2)
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