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Product Info Summary
| SKU: | A11412 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, IHC-P, WB |
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Product info
Product Name
Anti-Carabin TBC1D10C Antibody
SKU/Catalog Number
A11412
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Carabin TBC1D10C Antibody (Catalog # A11412). Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse.
Storage & Handling
Carabin antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Carabin TBC1D10C Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A11412)
Host
Rabbit
Contents
Carabin Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Carabin antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human Carabin. The immunogen is located within the last 50 amino acids of Carabin.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
SPINK2 antibody is predicted to not cross-react with other SPINK family members.
Reactive Species
A11412 is reactive to TBC1D10C in Human, Mouse
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
49712 MW
Background of carabin
Antigen binding by the T-cell receptor (TCR) is one of the critical first steps in the immune response, triggering a cascade of signaling pathways that ultimately lead to T-cell activation. Screening a yeast two-hybrid screen of a human T-cell cDNA library with calcineurin, a protein phosphatase involved in multiple signaling pathways including T-cell activation, resulted in the identification of Carabin, a member of the TBC1 domain family of proteins, as a calcineurin-binding protein. Unlike other members of the TBC1 domain protein family which are thought to have a role in regulating cell growth and differentiation, further experiments demonstrated that Carabin is part of a negative regulatory loop for the intracellular TCR signaling pathway as well as an inhibitor of the Ras signaling pathway, suggesting that Carabin may also mediate crosstalk between calcineurin and Ras. Carabin antibody does not recognize TBC1D10A or TBC1D10B. Carabin is known to exist in multiple isoforms.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A11412 is guaranteed for ELISA, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Carabin antibody can be used for detection of Carabin by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of Carabin in Daudi cell lysate with Carabin antibody at (A) 1 and (B) 2 μg/mL.
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Immunohistochemistry of Carabin in human spleen tissue with Carabin antibody at 2.5 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For TBC1D10C (Source: Uniprot.org, NCBI)
Gene Name
TBC1D10C
Full Name
Carabin
Weight
49712 MW
Alternative Names
EPI64C, CARABIN, Carabin, TBC1 domain family member 10C
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TBC1D10C, check out the TBC1D10C Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TBC1D10C: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Carabin TBC1D10C Antibody (A11412)
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