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Product Info Summary
| SKU: | A11369 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Calcipressin-2 RCAN2 Antibody
SKU/Catalog Number
A11369
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Calcipressin-2 RCAN2 Antibody (Catalog # A11369). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
RCAN2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Calcipressin-2 RCAN2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A11369)
Host
Rabbit
Contents
RCAN2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
RCAN2 antibody was raised against a 14 amino acid synthetic peptide near the center of human RCAN2. The immunogen is located within amino acids 70 - 120 of RCAN2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
AMIGO1 antibody is human, mouse, and rat reactive. AMIGO1 antibody is predicted to not cross-react with AMIGO2 or AMIGO3.
Reactive Species
A11369 is reactive to RCAN2 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
22025 MW
Background of RCAN2
Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle. Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin's activity. Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3. RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome. Multiple isoforms of RCAN2 are known to exist.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A11369 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
RCAN2 antibody can be used for detection of RCAN2 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of RCAN2 in 3T3 cell lysate with RCAN2 antibody at (A) 1 and (B) 2 μg/mL.
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Immunohistochemistry of RCAN2 in mouse brain tissue with RCAN2 antibody at 2.5 μg/mL.
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Immunofluorescence of RCAN2 in mouse brain tissue with RCAN2 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For RCAN2 (Source: Uniprot.org, NCBI)
Gene Name
RCAN2
Full Name
Calcipressin-2
Weight
22025 MW
Superfamily
RCAN family
Alternative Names
Csp2, MCIP2, ZAKI-4, Dscr1l1, Zaki4, Calcipressin-2, Calcineurin inhibitory protein ZAKI-4 RCAN2 CSP2, DSCR1L1, MCIP2, RCN2, ZAKI-4, ZAKI4 regulator of calcineurin 2 calcipressin-2|Down syndrome candidate region 1-like 1|Down syndrome critical region gene 1-like 1|myocyte-enriched calcineurin-interacting protein 2|thyroid hormone-responsive (skin fibroblasts)|thyroid hormone-responsive protein ZAKI-4
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on RCAN2, check out the RCAN2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for RCAN2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Calcipressin-2 RCAN2 Antibody (A11369)
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