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Calcipressin-2 Antibodies
AND RCAN2 ELISA kits, Calcipressin-2 Proteins
Many biological assays use antibodies to detect Calcipressin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Calcipressin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Calcipressin-2 antibodies...
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RCAN2 Overview
Facts about Calcipressin-2.
Calcipressin-2 (RCAN2)
Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.
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Gene Information
| Human | |
|---|---|
| Gene Name: | RCAN2 |
| Uniprot: | Q14206 |
| Entrez: | 10231 |
Family
| Belongs to: |
|---|
| RCAN family |
Alternative Names
Calcipressin 2 (Thyroid hormone-responsive protein ZAKI-4) (Down syndromecandidate region 1-like 1) (Myocyte-enriched calcineurin interacting protein2) (MCIP2); calcipressin-2; Down syndrome candidate region 1-like 1; Down syndrome critical region gene 1-like 1; DSCR1L1MCIP2ZAKI4RCN2; hRCN2; Myocyte-enriched calcineurin-interacting protein 2; regulator of calcineurin 2CSP2; thyroid hormone-responsive (skin fibroblasts); Thyroid hormone-responsive protein ZAKI-4; ZAKI-4
Molecular Weight
Mass (kDA):
21.997 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6p12.3 |
| Sequence: | 6; NC_000006.12 (46220730..46492067, complement) |
Tissue Specificity
Expressed in fibroblasts, heart, brain, liver, and skeletal muscle but not in placenta, lung, kidney and pancreas.
Diseases
- Down Syndrome
- Tumor Angiogenesis
- Pathologic Neovascularization
- Hypertrophy
- Learning Disorders
- Cardiac Hypertrophy
- Goiter
- Neoplasms
- Nervousness
- Thyroid Hormone Resistance Syndrome
Pathways
- Cell Proliferation
- Angiogenesis
- Endothelial Cell Proliferation
- Regulation Of Cell Cycle
- Cell Migration
- Brain Development
- Tube Formation
- Response To Starvation
- Ossification
- Muscle Atrophy
- Endothelial Cell Migration
PTMs
- Phosphorylation
- Carboxylation
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RCAN2
bosterbio.com/bosterbio-gene-info-cards/RCAN2
References
PMID: 8662924 by Miyazaki T., et al. Molecular cloning of a novel thyroid hormone-responsive gene, ZAKI-4, in human skin fibroblasts.
PMID: 12102656 by Cao X., et al. Novel human ZAKI-4 isoforms: hormonal and tissue-specific regulation and function as calcineurin inhibitors.