Anti-C14orf49 Antibody

Product Name

Anti-C14orf49 Antibody

View all Nesprin-3 Antibodies

SKU/Catalog Number

A13164

Size

100 µl

Form

Liquid

Description

Boster Bio Anti-C14orf49 Antibody (Catalog # A13164). Tested in WB applications. This antibody reacts with Human, Mouse.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-C14orf49 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A13164)

Host

Rabbit

Contents

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from internal of human C14orf49.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A13164 is reactive to SYNE3 in Human, Mouse

Reconstitution

Calculated molecular weight

112216 MW

Background of Nesprin-3

Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells.

Li W.B., Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
Heilig R., Nature 421:601-607(2003).
Ota T., Nat. Genet. 36:40-45(2004).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A13164 is guaranteed for WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blotting: 1:500~1:3000

Validation Images & Assay Conditions

Gene/Protein Information For SYNE3 (Source: Uniprot.org, NCBI)

Alternative Names

Nesprin-3;Nuclear envelope spectrin repeat protein 3;SYNE3;C14orf49; SYNE3 C14orf139, C14orf49, KASH3, LINC00341, NCRNA00341, NET53, Nesp3 spectrin repeat containing nuclear envelope family member 3 nesprin-3|KASH domain-containing protein 3|long intergenic non-protein coding RNA 341|nuclear envelope spectrin repeat protein 3|uncharacterized protein C14orf113

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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