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- Table of Contents
Facts about Nesprin-3.
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton.
The nucleocytoplasmic interactions created by the LINC complex play an essential role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning.Probable anchoring protein which tethers the nucleus into the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is needed for flow-induced centrosome polarization and directional migration in aortic endothelial cells.
Human | |
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Gene Name: | SYNE3 |
Uniprot: | Q6ZMZ3 |
Entrez: | 161176 |
Belongs to: |
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nesprin family |
chromosome 14 open reading frame 49; FLJ25605; MGC75267; nesprin-3; NET53
Mass (kDA):
112.216 kDA
Human | |
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Location: | 14q32.13 |
Sequence: | 14; NC_000014.9 (95407266..95516693, complement) |
Expressed in aortic endothelial cells (at protein level).
Nucleus outer membrane; Single-pass type IV membrane protein. Nucleus envelope. Rough endoplasmic reticulum.
PMID: 16330710 by Wilhelmsen K., et al. Nesprin-3, a novel outer nuclear membrane protein, associates with the cytoskeletal linker protein plectin.
PMID: 18396275 by Stewart-Hutchinson P.J., et al. Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness.