Nesprin-3 (SYNE3)

As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton.

The nucleocytoplasmic interactions created by the LINC complex play an essential role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning.

Probable anchoring protein which tethers the nucleus into the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is needed for flow-induced centrosome polarization and directional migration in aortic endothelial cells.