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Product Info Summary
| SKU: | A00703 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-C-C motif chemokine 4 CCL4 Antibody
View all CCL4/MIP-1 beta Antibodies
SKU/Catalog Number
A00703
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-C-C motif chemokine 4 CCL4 Antibody (Catalog # A00703). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
CCL4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-C-C motif chemokine 4 CCL4 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00703)
Host
Rabbit
Contents
CCL4 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Rabbit polyclonal CCL4 antibody was raised against a 15 amino acid peptide near the center of human CCL4. The immunogen is located within the first 50 amino acids of CCL4.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
SHBG antibody is human, mouse, and rat reactive. At least three isoforms of SHBG are known to exist; this antibody will detect all three isoforms.
Reactive Species
A00703 is reactive to CCL4 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
10212 MW
Background of CCL4/MIP-1 beta
CCL4, also known as macrophage inflammatory protein 1-beta (MIP1B), belongs to the intercrine beta (chemokine CC) family. Both CCL4 and the related protein CCL3 participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells. While both CCL4 and CCL3 exert similar effects on monocytes, their effect on lymphocytes differ; with CCL4 selectively attracting CD4+ lymphocytes and CCL3 selectively attracting CD8+ lymphocytes. Additionally, both have been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. The processed form of CCL4 can induce down-modulation of surface expression of the chemokine receptor CCR5, thus inhibiting the CCR5-mediated entry of HIV-1 in T cells.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A00703 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
CCL4 antibody can be used for detection of CCL4 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of CCL4 in rat brain tissue lysate with CCL4 antibody at 1 μg/mL.
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Immunohistochemistry of CCL4 in rat brain tissue with CCL4 antibody at 2.5 μg/ml.
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Immunofluorescence of CCL4 in rat brain tissue with CCL4 antibody at 20 μg/ml.
Protein Target Info & Infographic
Gene/Protein Information For CCL4 (Source: Uniprot.org, NCBI)
Gene Name
CCL4
Full Name
C-C motif chemokine 4
Weight
10212 MW
Superfamily
intercrine beta (chemokine CC) family
Alternative Names
ACT2, G-26, HC21, LAG1, LAG-1, MIP1B, SCYA2, SCYA4, MIP1B1, AT744.1, MIP-1-beta, C-C motif chemokine 4, G-26 T-lymphocyte-secreted protein CCL4 ACT2, AT744.1, G-26, HC21, LAG-1, LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4 C-C motif chemokine ligand 4 C-C motif chemokine 4|G-26 T-lymphocyte-secreted protein|MIP-1-beta(1-69)|PAT 744|SIS-gamma|T-cell activation protein 2|chemokine (C-C motif) ligand 4|lymphocyte activation gene 1 protein|macrophage inflammatory protein 1-beta|secreted protein G-26|small inducible cytokine A4 (homologous to mouse Mip-1b)
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on CCL4, check out the CCL4 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for CCL4: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-C-C motif chemokine 4 CCL4 Antibody (A00703)
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