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Product Info Summary
| SKU: | A01552-2 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, ICC, WB |
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Product info
Product Name
Anti-Bim EL BCL2L11 Antibody
SKU/Catalog Number
A01552-2
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Bim EL BCL2L11 Antibody (Catalog # A01552-2). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Bim EL antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-Bim EL BCL2L11 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01552-2)
Host
Rabbit
Contents
Bim EL Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Bim EL antibody was raised against a peptide corresponding to 15 amino acids near the amino terminus of human Bim. The immunogen is located within amino acids 20 - 70 of Bim EL.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Bim EL antibody is human and mouse reactive. Multiple isoforms of Bim are known to exist; this antibody only detects the Bim EL isoform.
Reactive Species
A01552-2 is reactive to BCL2L11 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
22171 MW
Background of BCL2L11
Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. Bim, also known as Bcl-2-like protein 11, is a pro-apoptotic member of this family and interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Multiple isoforms of Bim are known to exist, with Bim EL being the longest isoform (1,2).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A01552-2 is guaranteed for ELISA, IF, ICC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Bim EL antibody can be used for detection of Bim EL by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of Bim in K562 cell lysate with Bim EL antibody at (A) 1 and (B) 2 μg/mL.
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Immunocytochemistry of BIM EL inK562 cells with BIM EL antibody at 2.5 μg/ml.
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Immunofluorescence of BIM EL in K562 cells with BIM EL antibody at 2.5 μg/ml.
Protein Target Info & Infographic
Gene/Protein Information For BCL2L11 (Source: Uniprot.org, NCBI)
Gene Name
BCL2L11
Full Name
Bcl-2-like protein 11
Weight
22171 MW
Superfamily
Bcl-2 family
Alternative Names
BAM, BIM, BOD, Bcl-2-like protein 11, Bcl2-interacting mediator of cell death, Bcl2-L-11 BCL2L11 BAM, BIM, BOD BCL2 like 11 bcl-2-like protein 11|BCL2-like 11 (apoptosis facilitator)|bcl-2 interacting mediator of cell death|bcl-2 interacting protein Bim|bcl-2-related ovarian death agonist
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on BCL2L11, check out the BCL2L11 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for BCL2L11: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Bim EL BCL2L11 Antibody (A01552-2)
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