Bcl-2-like protein 11 Antibodies

Bcl-2-like protein 11 (BCL2L11)

Induces apoptosis and anoikis. Isoform BimL is significantly more potent than isoform BimEL.

Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less powerful than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis.

Gene Information

Human
Gene Name:	BCL2L11
Uniprot:	O43521
Entrez:	10018

Family

Belongs to:
Bcl-2 family

Alternative Names

BAM; bcl-2 interacting mediator of cell death; bcl-2 interacting protein Bim; Bcl2-interacting mediator of cell death; bcl2-L-11; BCL2-like 11 (apoptosis facilitator); bcl-2-like protein 11; bcl-2-related ovarian death agonist; BIM-alpha6; BIM-beta6; BIM-beta7; BIMBOD; BimEL; BimL

Molecular Weight

Mass (kDA):
22.171 kDA

Genomic Context

Human
Location:	2q13
Sequence:	2; NC_000002.12 (111120914..111168445)

Tissue Specificity

Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are widely expressed with tissue- specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney.

Subcellular Localizations

Endomembrane system; Peripheral membrane protein. Associated with intracytoplasmic membranes.; [Isoform BimEL]: Mitochondrion. Translocates from microtubules to mitochondria on loss of cell adherence.; [Isoform BimL]: Mitochondrion.; [Isoform BimS]: Mitochondrion.; [Isoform Bim-alpha1]: Mitochondrion.

Diseases

• Malignant Neoplasms
• Neoplasms
• Leukemia
• Acute Lymphocytic Leukemia
• Lymphoma
• Lymphoma, Non-hodgkin
• Carcinoma
• Adenocarcinoma
• Precursor T-cell Lymphoblastic Leukemia-lymphoma
• Leukemogenesis
• Malignant Neoplasm Of Stomach
• Mammary Neoplasms
• Diabetes Mellitus

• Diabetes Mellitus, Non-insulin-dependent
• Autoimmunity
• Intestinal Diseases
• Chromosomal Translocation
• Lymphatic Diseases
• Inflammatory Response
• Leukemia, Myelocytic, Acute

Interacting Proteins

• BAD
• BAX
• BCL2
• BCL2A1
• Bcl2a1

• BCL2L1
• BCL2L10
• BCL2L2
• MCL1
• Mcl1

• MIF
• RACK1

Pathways

• Cell Death
• Cell Cycle
• Cell Cycle Arrest
• Pathogenesis
• Cell Proliferation
• Rna Interference
• Transport
• Immune Response
• Inflammatory Response
• Translation
• Induction Of Apoptosis
• Dna Methylation
• Methylation

• Cell Growth
• Cell Adhesion
• Programmed Cell Death
• Dna Hypermethylation
• Electron Transport
• Cellular Homeostasis
• Fertilization

PTMs

• Phosphorylation
• Methylation

• Deacetylation
• Cleavage

• Acetylation

Research Areas

• Apoptosis
• Cancer
• Immunology
• Innate Immunity
• Tumor Suppressors

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BCL2L11

Best Uses Of The BCL2L11 Marker

If you're considering buying an antibody against the BCL2L11 protein you've probably heard about the rabbit polyclonal antibody Anti-HCRP-1. The anti-HCRP-1 antibody is available from Proteintech (Wuhan, China) and the rabbit monoclonal antibody against p-ERK and EGFR is available from Selleck.

Anti-HCRP-1 rabbit polyclonal antibody

This antibody targets HCRP-1, which is an oncogene found in cancer cells. The antibody was initially isolated from hepatocellular carcinoma lines, and its expression in these tumors is associated with poor prognosis. Many studies have looked into the role of HCRP-1 in the process of tumorigenesis. It has also been shown to affect the sensitivity of cetuximab and the prognostic value of EGFR.

Boster Bio's MA1115 product is available on the market. This antibody has been tested in several applications including IP, IHC and WB. It is also available in liquid form. It can also be purchased as a blocking peptide at additional costs. Boster Bio's Antibody MA1115 is highly recommended since it interacts with the body's HCRP-1 protein.

Boster Bio uses a unique chemistry to produce rabbit mAbs that have high affinity. Boster Bio's PCD technology lets them select one epitope and minimize variability when it comes to the specificity of polyclonal antibodies. As a result, clones with high brightness are suitable for downstream screening. Once the antibody is accepted, it can be utilized in clinical settings.

The expression of the HCRP-1 protein in TMA slides was assessed using 100 CRC tumors and 8 non-cancerous tissues. In this experiment the staining of cytoplasmic HCRP-1 was observed in 58.1 percent of patients with CRC compared to 78.6 percent of normal colon tissues. While the levels of HCRP-1 within CRC tumors were low however, they were found to be associated with clinicopathological characteristics of the patients.

The antibody was generated using a method described previously15. A TMA slide was stained using the rabbit polyclonal antibody to the HCRP-1 virus. Then, it was followed by the control virus. After incubation, the samples were subjected to puromycin for two weeks. The immunoreactivity was evaluated by two independent observers using an optical microscope. Positive results mean that at least 10 percent of tumor cells are positive.

In a study of mice, HCRP-1 knockdown mice had significantly higher levels than the control group of metastatic lung nodules in a study. This antibody offers many advantages. Its high affinity to HCRP-1 reduces inflammation that stimulates tumor growth and metastasis. The antibody also inhibits the inflammatory response of tumor cells and boosts BIM expression.

Anti-p-AKT rabbit polyclonal antibody

Boster Bio's Anti p-AKT rabbit monoclonic antibody reacts with Human. It binds to the Ser473 amino acids of phosphorylated Akt. This product is suitable for ELISA, Flow Cytometry, and immunohistochemistry applications. The antibody is stable at -20°C and can be reused up to one year. Blocking peptides can increase the lifespan of the antibody for up to a month.

Anti-p-EGFR rabbit polyclonal antibody

Anti-p-EGFR rabbit polyclonic antibody is available from Boster Bio. It recognizes the pThr693 region of the human EGFR protein. The antibody has been tested using ELISA, WB, and ICC. It is compatible with rats and mice. The product is stable up to 20 degrees Celsius. Do not freeze or freeze the antibody solution again.

Many companies make antibodies that recognize specific antigens. Some companies specialize in developing specific antibodies to identify diseases. Cosmo Bio Company is an international distributor of monoclonal antibodies, while Virusys is a specialist in antibody-based diagnostic kits. HyTest is another company that provides immunological kits and reagents for research. Their product line also includes products for infectious diseases, veterinary medicine, and immune-mediated diseases.

Alpha Diagnostic International is another company that sells monoclonal antibody. The company provides a variety of antibodies which include an antibody from a rabbit that is polyclonal to EGFR. They are also available for clinical trials and can be used for research for research purposes. Alpha Diagnostic International also offers various tests for the diagnosis of diseases and custom peptides. The company also provides customer reviews and protocols.

Boster Bio's Antip-EGFR Rabbit Polyclonal Antibody is able to treat a variety of tumors. EGFR overexpression has been linked to lung cancer, squamous cell bladder cancer, as well as breast cancer. EGFR is also associated with a poor prognosis for various types of tumors. This is why EGFR rabbit polyclonal antibody is a crucial therapeutic tool for EGFR-positive NSCLC with HER2-overexpressed.

The scFv-9R protein can also be used to target cancers that are EGFR positive. The scFv-9R may be used to metabolize siRNAs in the kidneys of patients as well as the liver. It is also effective in treating a large variety of cancers. It is currently approved for lung adenocarcinoma and is in clinical trials for other solid tumors.

If you're in search of a high-quality rabbit polyclonal antibody There's a high chance you'll find it on Amazon.com. This company sells high-quality monoclonal and polyclonal antibodies as well as cell culture-specific ELISA kit kits. These products are available in quantity pricing and come with a money back guarantee. The company also offers a range of other products , including Recombinant Proteins or ELISA kits.