Human recombinant R-spondin 1 protein, AF

Product Name

Human recombinant R-spondin 1 protein, AF

View all R-Spondin 1 recombinant proteins

SKU/Catalog Number

PROTQ2MKA7-1

Size

5ug,20ug,100ug

Tag

His-SUMO Tag (N-term)

Description

R-spondin 1 (RSPO1, Roof plate-specific Spondin 1) is a cysteine-rich secreted glycoprotein that belongs to the R-Spondin family. Structurally, R-spondin 1 harbors an N-terminal signal peptide, two cysteine-rich furin-like (FU1-FU2) domains, a thrombospondin (TSP) domain, and a basic amino acid-rich (BR) C-terminal domain. R-spondin 1 acts as a ligand for the leucine-rich repeat-containing G-protein coupled receptor (LGR) family (LGR4/5/6), subsequent clearing negative regulators ZNRF3/RNF43 from the membrane, leading to the availability of Wnt receptor and activating Wnt/β-catenin signaling. The signal cascade is essential for regulating stem cell proliferation, embryonic development, and tissue homeostasis.

Storage & Handling

Store at 2°C to 8°C for up to 2 weeks, -20°C or -80°C for 6 months. Further dilute in a buffer containing a carrier protein or stabilizer (e.g. 0.1% BSA, 10%FBS, 5%HSA or 5% trehalose solution), protein aliquots should be stored at -20°C or -80°C for 3-6 months. Avoid repeated freeze/thaw cycles.

Cite This Product

Human recombinant R-spondin 1 protein, AF (Boster Biological Technology, Pleasanton CA, USA, Catalog # PROTQ2MKA7-1)

Form

Liquid

Formulation

Liquid (1X PBS, pH 7.4) If you have any concerns or special requirements, please confirm with us.

Purity

>95% as determined by SDS-PAGE.

Predicted MW

29.332kDa

Validation Images & Assay Conditions

Gene/Protein Information For RSPO1 (Source: Uniprot.org, NCBI)

Alternative Names

RSPO1, Roof plate-specific spondin-1 Rspo1|R, R-, R-spondin, Rspondin|R-spondin 1|R-spondin-1|R-spondin homolog|cristin-3|cysteine-rich and single thrombospondin domain-containing protein 3|mCristin-3|roof plate-specific spondin-1|thrombospondin type 1 domain containing gene Rspondin

*If product is indicated to react with multiple species, protein information is based on the gene entry specified above in "Species".

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