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R-spondin-1 Antibodies
AND Rspo1 ELISA kits, R-spondin-1 Proteins
Many biological assays use antibodies to detect R-spondin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with R-spondin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop R-spondin-1 antibodies...
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Rspo1 Infographic by Boster Bio
All Rspo1 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$750
Cat # EK1516
96 wells/kit, with removable strips.
Cat # EK1516
96 wells/kit, with removable strips.
Human, Mouse, Rat
IHC, WB
$523
Cat # M02857
100 µl
Cat # M02857
100 µl
Human
ELISA
$499
Cat # FEK1516
96 wells/kit, with removable strips.
Cat # FEK1516
96 wells/kit, with removable strips.
Rspo1 Overview
Facts about R-spondin-1.
R-spondin-1 (Rspo1)
Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors which are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes (PubMed:21693646). Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway.
Acts as a ligand for frizzled FZD8 and LRP6. May negatively modulate the TGF-beta pathway.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Rspo1 |
| Uniprot: | Q9Z132 |
| Entrez: | 192199 |
Family
| Belongs to: |
|---|
| R-spondin family |
Alternative Names
Cristin 3; CRISTIN3; FLJ40906Roof plate-specific spondin-1; HRspo1; roof plate-specific spondin; RSPO; RSPO1; RSpondin 1; R-Spondin 1; R-spondin homolog (Xenopus laevis); RSPONDIN; R-spondin1; R-spondin-1
Molecular Weight
Mass (kDA):
29.332 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 4|4 D2.2 |
| Sequence: | 4; |
Tissue Specificity
Expressed in the dorsal part of the neural tube on 10 and 12 dpc, especially in the boundary region between roof plate and neuroepithelium. This expression is enhanced in the rostral part. Also expressed in other tissues such as truncal region neighboring forelimbs and mesenchymal tissues around the nasal cavity.
Diseases
- Disorders Of Sex Development
- Malignant Neoplasms
- Carcinoma
- True Hermaphroditism (disorder)
- Neoplasms
- Gonadal Dysgenesis
- Pathologic Neovascularization
- Hermaphroditism
- Skin Neoplasms
- Tissue Adhesions
- Mucositis
- Palmoplantar Keratosis
- Ovotesticular Disorders Of Sex Development
Pathways
- Sex Determination
- Cell Differentiation
- Cell Proliferation
- Regeneration
- Cell Growth
- Meiosis
- Gonad Development
- Sertoli Cell Differentiation
- Localization
- Sex Differentiation
- Secretion
- Female Sex Determination
- Cell Migration
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Rspo1
bosterbio.com/bosterbio-gene-info-cards/Rspo1
References
PMID: 14732490 by Kamata T., et al. R-spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutants.
PMID: 15469841 by Kazanskaya O., et al. R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis.