R-spondin-1 Antibodies

R-spondin-1 (Rspo1)

Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors which are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes (PubMed:21693646). Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway.

Acts as a ligand for frizzled FZD8 and LRP6. May negatively modulate the TGF-beta pathway.

Gene Information

Mouse
Gene Name:	Rspo1
Uniprot:	Q9Z132
Entrez:	192199

Family

Belongs to:
R-spondin family

Alternative Names

Cristin 3; CRISTIN3; FLJ40906Roof plate-specific spondin-1; HRspo1; roof plate-specific spondin; RSPO; RSPO1; RSpondin 1; R-Spondin 1; R-spondin homolog (Xenopus laevis); RSPONDIN; R-spondin1; R-spondin-1

Molecular Weight

Mass (kDA):
29.332 kDA

Genomic Context

Mouse
Location:	4|4 D2.2
Sequence:	4;

Tissue Specificity

Expressed in the dorsal part of the neural tube on 10 and 12 dpc, especially in the boundary region between roof plate and neuroepithelium. This expression is enhanced in the rostral part. Also expressed in other tissues such as truncal region neighboring forelimbs and mesenchymal tissues around the nasal cavity.

Diseases

• Disorders Of Sex Development
• Malignant Neoplasms
• Carcinoma
• True Hermaphroditism (disorder)
• Neoplasms
• Gonadal Dysgenesis
• Pathologic Neovascularization
• Hermaphroditism
• Skin Neoplasms
• Tissue Adhesions
• Mucositis
• Palmoplantar Keratosis
• Ovotesticular Disorders Of Sex Development

• Leukemia
• Neoplasms, Experimental
• Congenital Abnormality
• Arthritis
• Skin Carcinoma
• Ovarian Failure, Premature
• Gastrointestinal Diseases

Pathways

• Sex Determination
• Cell Differentiation
• Cell Proliferation
• Regeneration
• Cell Growth
• Meiosis
• Gonad Development
• Sertoli Cell Differentiation
• Localization
• Sex Differentiation
• Secretion
• Female Sex Determination
• Cell Migration

• Osteoblast Differentiation
• Spermatogenesis
• Dna Methylation
• Insulin Secretion
• Methylation
• Bone Remodeling
• Male Sex Determination

PTMs

• Phosphorylation

• Methylation

• Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Rspo1

Boster Bio - Best Uses Of The RSPO1 Marker

Boster Bio has a variety of optimization options to suit any experimental set-up. Learn about the company and Steven Boster's background in this short article. Additionally, you will find optimization guides and tips that will help you optimize your experiments. Boster Bio, a company employing over 100 people, can help you with all your experiments. The RSPO1 mark is a protein used for identifying rhodopsin, a genetic component responsible for the formation and maintenance of DNA.

Boster Biologicals' products

Boster Biologicals is a top manufacturer of immunological reagents. Their products include picogram-sensitivity polyclonal antibodies and ELISA kits. Their products were tested against 250 samples in order to confirm their high affinity and quantitative detection. They have extensive expertise in developing and optimizing immunogens. Their products are widely used for research, industry, life sciences, and other purposes.

The LGR5-Ras pathway induces intestinal stem cell production after tissue injury. The RSPO1 marker is a key component. RSPO2 & RSPO3 were found to correlate with colon and liver cancers, respectively. These markers are crucial for cell proliferation and differentiation, survival, as well as tissue homeostasis. RSPOs, in addition to many other functions, are critical for liver, intestinal, epithelial and epithelial stem-cell induction.

The key event in liver fibrogenesis is activation HSCs. More information is available on the intracellular events that trigger HSC activation. RSPO, also known by roof plate-specific spondin (or roof plate-specific spondin), activates the Wnt signaling pathway. It also enhances the activity and potency of b-catenin. RSPO, one of four homologous amino proteins, plays a variety of physiological functions.

RSPOs have been shown to be involved in hepatic fibrogenesis. RSPOs are a strong target for early detection because they correlate with the stages of fibrosis. Additionally, RSPOs also produce proteins that are expressed during activation by HSCs. This means that they can initiate and continue liver fibrosis.

History of Steven Boster

If you want to know more about Steve Boster, you've come to the right place. Public records for Steve Boster are available here, including his current and previous addresses, mobile phone numbers, email addresses, and known relatives. You can also search for Steve Boster's address and age and filter results by state to find out more specific information about him. You can use the information to learn more about this entrepreneur.

Steve Boster, a Chicago native, was born on February 16, 1923. He was a Concordia Hall member from Staunton, VA. He served his country in the U.S. Army, earning the Purple Heart. His son Jonathan Boster and grandson Cory Boster are also survivors. Evelyn Boster was a nurse. Many nieces and nephews also survived him.

Optimization tips

There are many options for flow procedures, whether you're doing IHC experiments for the RSPO1 antibody or for another antibody. Here are some common questions. This article will cover both positive and negative control conditions. Boster Bio's optimization tools will help you optimize your experiments. This guide is useful for anyone using Boster Bio products.