This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
APP Antibodies
AND APP ELISA kits, APP Proteins
Many biological assays use antibodies to detect APP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with APP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop APP antibodies...
Previous: A1BG
Next: ABCC6
APP Infographic by Boster Bio
All APP Products
Product
Figures
Specificity
Applications
Price
Anti-beta Amyloid/APP Antibody Picoband®
10 Citations 17 Q&As
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # PB9091
100 μg/vial
Cat # PB9091
100 μg/vial
Anti-Beta Amyloid APP Antibody
3 Citations 16 Q&As
Human, Mouse
ELISA, IF, IHC, WB
$598
Cat # A00081-2
100ug
Cat # A00081-2
100ug
Anti-Amyloid beta A4 APP Rabbit Monoclonal Antibody
5 Citations 16 Q&As
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00081
100 μl
Cat # M00081
100 μl
Human, Mouse, Rat
ELISA
$540
Cat # EKC1937
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC1937
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA, IHC-P, WB
$449
Cat # A00081
0.1 mg
Cat # A00081
0.1 mg
Human, Mouse, Rat
IHC, WB
$482
Cat # A00081T668-1
100ul
Cat # A00081T668-1
100ul
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A00081T743
100ul
Cat # A00081T743
100ul
Human, Mouse, Rat
Flow Cytometry, IF, IHC, WB
$523
Cat # M00081-1
100 µl
Cat # M00081-1
100 µl
Cynomolgus monkey, Human, Mouse
ELISA, Flow Cytometry, FTA
$349
Cat # M00081-2
100 μg
Cat # M00081-2
100 μg
APP Overview
Facts about Amyloid-beta precursor protein.
Amyloid-beta precursor protein (APP)
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb.
Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | APP |
| Uniprot: | P05067 |
| Entrez: | 351 |
Family
| Belongs to: |
|---|
| APP family |
Alternative Names
Abeta; Amyloid beta; beta-Amyloid Peptide
Molecular Weight
Mass (kDA):
86.943 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 21q21.3 |
| Sequence: | 21; NC_000021.9 (25880550..26171128, complement) |
Tissue Specificity
Expressed in all fetal tissues examined with highest levels in brain, kidney, heart and spleen. Weak expression in liver. In adult brain, highest expression found in the frontal lobe of the cortex and in the anterior perisylvian cortex- opercular gyri. Moderate expression in the cerebellar cortex, the posterior perisylvian cortex-opercular gyri and the temporal associated cortex. Weak expression found in the striate, extra- striate and motor cortices. Expressed in cerebrospinal fluid, and plasma. Isoform APP695 is the predominant form in neuronal tissue, isoform APP751 and isoform APP770 are widely expressed in non- neuronal cells. Isoform APP751 is the most abundant form in T- lymphocytes. Appican is expressed in astrocytes.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Perikaryon. Cell projection, growth cone. Membrane, clathrin-coated pit. Early endosome. Cytoplasmic vesicle. Cell surface protein that rapidly becomes internalized via clathrin-coated pits. Only a minor proportion is present at the cell membrane; most of the protein is present in intracellular vesicles (PubMed:20580937). During maturation, the immature APP (N-glycosylated in the endoplasmic reticulum) moves to the Golgi complex where complete maturation occurs (O-glycosylated and sulfated). Afte
Diseases
- Alzheimer's Disease
- Plaque, Amyloid
- Senile Plaques
- Dental Plaque
- Dementia
- Nerve Degeneration
- Neurodegenerative Disorders
- Neurofibrillary Tangles
- Neuroblastoma
- Alzheimer Disease, Familial
- Inflammation
- Impaired Cognition
- Nervousness
Pathways
- Pathogenesis
- Secretion
- Proteolysis
- Transport
- Aging
- Localization
- Cell Death
- Protein Processing
- Cognition
- Endocytosis
- Secretory Pathway
- Hyperphosphorylation
- Translation
PTMs
- Cleavage
- Phosphorylation
- Glycosylation
- Oxidation
- Gamma-cleavage
- Reduction
- Biotinylation
- Methylation
- Dephosphorylation
- Ubiquitination
Research Areas
- Alzheimers Research
- Apoptosis
- Cell Cycle and Replication
- Neurodegeneration
- Neuronal Cell Markers
- Neuroscience
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/APP
bosterbio.com/bosterbio-gene-info-cards/APP
References
PMID: 2881207 by Kang J., et al. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor.
PMID: 2893289 by Ponte P., et al. A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors.
13 Publications of Boster APP Antibodies & ELISA Kits
- PubMed ID: 10.1007/s12264-011-1028-2, Combined administration of D -galactose and aluminium induces Alzheimerlike lesi...
- PubMed ID: 32951326, Zhang L,Zhang J,Gong Y,Lv L.Systematic and experimental investigations of the an...
- PubMed ID: -, Ou Qiao,Xinyu Zhang,Yi Zhang et al.Cerebralcare Granule® enhances memantine hyd...
- PubMed ID: 33737111, Gong YS, Hou FL, Guo J, Lin L, Zhu FY. Effects of Alcohol Intake on Cognitive Fu...
- PubMed ID: 32427716, Wu J,Qu JQ,Zhou YJ,Zhou YJ,Li YY,Huang NQ,Deng CM,Luo Y.Icariin improves cogniti...
- PubMed ID: 30072873, Adapentpronitrile, a New Dipeptidyl Peptidase-IV Inhibitor, Ameliorates Diabetic...
- PubMed ID: 26459718, Anti-autophagic and anti-apoptotic effects of memantine in a SH-SY5Y cell model ...
- PubMed ID: 23437066, Neuroprotective Effect of Kaempferol Glycosides against Brain Injury and Neuroin...
- PubMed ID: 29163135, Kuang X, Zhou HJ, Thorne AH, Chen XN, Li LJ, Du JR. Front Aging Neurosci. 2017 N...
- PubMed ID: 22594104, Qin Ra, Yao Xx, Huang Zy. J Tradit Chin Med. 2012 Mar;32(1):63-6. Effects Of Com...
- PubMed ID: 24806610, Sun L, Zhou Xl, Yi Hp, Jiang Sj, Yuan H. Biotech Histochem. 2014 Oct;89(7):513-7...
- PubMed ID: 22061800, Li Wz, Li Wp, Huang Dk, Kan Hw, Wang X, Wu Wy, Yin Yy, Yao Yy. Behav Brain Res. ...
- PubMed ID: 19782061, Nie J, Luo Y, Huang Xn, Gong Qh, Wu Q, Shi Js. Eur J Pharmacol. 2010 Jan 25;626(...
*More publications can be found for each product on its corresponding product page