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CEMIP Antibodies
AND CEMIP ELISA kits, CEMIP Proteins
Many biological assays use antibodies to detect CEMIP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CEMIP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CEMIP antibodies...
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CEMIP Overview
Facts about Cell migration-inducing and hyaluronan-binding protein.
Cell migration-inducing and hyaluronan-binding protein (CEMIP)
Mediates depolymerization of hyaluronic acid (HA) through the cell membrane-associated clathrin-coated pit endocytic pathway. Hydrolyzes high molecular weight hyaluronic acid to make an intermediate-sized product, a process that might occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes.
Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial- mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination.
Gene Information
| Human | |
|---|---|
| Gene Name: | CEMIP |
| Uniprot: | Q8WUJ3 |
| Entrez: | 57214 |
Family
| Belongs to: |
|---|
| CEMIP family |
Alternative Names
CCSP1; CEMIP; colon cancer secreted protein 1; IR2155535; KIAA1199; TMEM2L
Molecular Weight
Mass (kDA):
152.998 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 15q25.1 |
| Sequence: | 15; NC_000015.10 (80779370..80951771) |
Tissue Specificity
Expressed in dermal and in synovial fibroblasts. Strongly expressed in gastric cancers compared with the paired normal tissues. Strongly expressed in both ductal carcinoma and invasive breast cancer cells compared with benign epithelial cells (at protein level). Strongly expressed in brain, placenta, prostate, breast, lung and testis. Expressed in fibroblasts, epithelial cells and cancer cells. In ear, it is specifically expressed in inner ear. Expressed in cochlea and vestibule tissues. Strongly expressed in gastric cancers compared with the paired normal tissues. Strongly expressed in colon adenocarcinomas compared with normal colonic mucosas. Strongly expressed in breast cancer as compared to normal breast tissue.
Subcellular Localizations
Nucleus. Cytoplasm. Endoplasmic reticulum. Cell membrane. Membrane, clathrin-coated pit. Secreted. Retained in the endoplasmic reticulum (ER) in a HSPA5/BIP-dependent manner. Colocalized with clathrin heavy chain/CLTC in clathrin-coated vesicles. Strongly detected in the cytoplasm of breast carcinoma cells, whereas poorly detected in adjacent normal epithelial cells, stromal cells, or benign breast tissues. Localized in the nucleus and cytoplasm of colon adenocarcinomas.
Diseases
- Malignant Neoplasms
- Adenoma
- Neoplasms
- Adenocarcinoma
- Colorectal Neoplasms
- Neoplasm Metastasis
- Colorectal Cancer
- Complete Hearing Loss
- Cell Transformation, Neoplastic
- Stomach Neoplasms
- Metastatic Malignant Neoplasm To The Lymph Node
- Malignant Neoplasm Of Breast
- Malignant Tumor Of Colon
Pathways
- Methylation
- Localization
- Senescence
- Replicative Senescence
- Gastric Motility
- Reverse Transcription
- Cell Cycle
- Aging
PTMs
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CEMIP
bosterbio.com/bosterbio-gene-info-cards/CEMIP
References
PMID: 14577002 by Abe S., et al. Mutations in the gene encoding KIAA1199 protein, an inner-ear protein expressed in Deiters' cells and the fibrocytes, as the cause of nonsyndromic hearing loss.
PMID: 16157444 by Michishita E., et al. Upregulation of the KIAA1199 gene is associated with cellular mortality.