ZC3HAV1 Antibodies

Zinc finger CCCH-type antiviral protein 1 (ZC3HAV1)

Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)- specific ribonuclease PARN to remove the poly(A) tail, and the 3'- 5' exoribonuclease complex exosome to degrade the RNA body in the 3'-end.

Additionally, it recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to commence its own degradation from the 5'-end. Its target viruses belong to families including retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV).

Gene Information

Human
Gene Name:	ZC3HAV1
Uniprot:	Q7Z2W4
Entrez:	56829

Family

Belongs to:
No superfamily

Alternative Names

FLB6421DKFZp686O19171; FLJ13288antiviral 1; ZAPDKFZp686F2052; ZC3HDC2DKFZp686H1869; Zinc finger antiviral protein; Zinc finger CCCH domain-containing protein 2; zinc finger CCCH-type antiviral protein 1; zinc finger CCCH-type, antiviral 1

Molecular Weight

Mass (kDA):
101.431 kDA

Genomic Context

Human
Location:	7q34
Sequence:	7; NC_000007.14 (139043515..139109720, complement)

Subcellular Localizations

[Isoform 1]: Cytoplasm. Nucleus. Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner.; [Isoform 2]: Cytoplasm.

Diseases

• Infective Disorder
• Sclerosis
• Influenza
• Urticaria
• Infectious Mononucleosis
• Multiple Sclerosis
• Influenza In Birds
• Aids Dementia Complex
• Encephalitis

• Headache
• Hiv Infections
• Inflammation

Interacting Proteins

• DDX58

Pathways

• Developmental Process
• Metabolic Process
• Response To Stimulus
• Biological Regulation
• Post-translational Protein Modification
• Cognition
• Primary Metabolic Process

• Chromatin Remodeling

PTMs

• Acetylation

• Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ZC3HAV1

Boster Bio: Best Uses Of The ZC3HAV1 Marker

In this article, we will explore the Boster Bio Anti–ZC3HAV1 marker and High-affinity primary antibodies. We will also explore how Boster Bio developed the ZC3HAV1 antibodies in rabbit and mouse. We'll also talk about the special samples that Boster scientists used with the ZC3HAV1Marker.

Boster Bio Anti-ZC3HAV1 Marker

Boster Bio is an anti-body manufacturer that specializes on picogram sensitivity ELISA kits as well as IHC-optimized, polyclonal antibody manufacturing. Boster Bio has more than 12,000 antibodies available for IHC, WB and Flow applications. These antibodies were validated against 250 tissue samples and untransfected cell line lines. The anti-ZC3HAV1 marker is designed to be used for both quantitative as well as qualitative analysis. It can detect and quantify protein levels in high and low concentrations in a variety of samples.

Boster Bio Anti ZC3HAV1 virus marker can both be used in conventional and recombinant DNA technology. Studies on human blood samples have shown that this anti-ZC3HAV1 antibody marker is effective. It is highly recommended that it be used in custom and beNeLux services. Sanbio provides more information on this gene treatment. They can help with customization and BeNeLux delivery.

Boster Bio High-affinity Primary Anabolies

In order to perform flow cytometry, scientists use antibodies to detect ZC3HAV1. These antibodies can react with many animal samples, and can be monoclonal (or polyclonal) Boster Bio uses both rabbit and mouse as the sources of antibodies for ZC3HAV1.

To determine whether the antibody has a specificity, the immunoglobulins of the host immune are taken. These antibodies are made with two main building blocks: specificities and affinities. Higher affinity indicates greater specificity. A lower specificity indicates less accuracy. A good primary antibody is capable of detecting, purifying, and measuring the target protein.

Secondary antibodies are used for labeling samples. Secondary antibodies may be used to confirm the primary antigen. By using both antibodies, researchers can answer more questions with their specimens. This provides more context and solid answers. High-affinity primary antibody against ZC3HAV1 (high-affinity) will detect the presence or absence HIV-1. This kit has dual-labeling capabilities that allow for detection of viral infections.

Boster Bio Mouse, Rabbit to Create ZC3HAV1 Immunobodies

Boster Bio has developed ZC3HAV1 antibodies from a rabbit and mouse model. The rabbit mAbs have high affinity and specificity and can be used in a variety of scientific, medical, and diagnostic applications. The company uses its proprietary plasma cell discovery technology to screen individual cells treated with a chemistry that inhibits secretion of antibodies and retains them on cell membranes. Boster Bio scientists use plasma cells and splenocytes incubated with antigens in order to develop antibodies.

The rabbit monoclonal antibodies are highly specific and retain their specificity in strict applications. Rabbits' immune system has the capacity to produce antibodies against small epitopes and can detect subtle differences in PTMs. Their immune system also has a greater diversity and is better characterized, which allows them more epitopes to be detected. These antibodies are produced in between four and six weeks.