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Protein zwilch homolog Antibodies

AND ZWILCH ELISA kits, Protein zwilch homolog Proteins

Many biological assays use antibodies to detect Protein zwilch homolog, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein zwilch homolog in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein zwilch homolog antibodies...

We validate the specificity of these antibodies to Protein zwilch homolog by testing them on tissues known to express ZWILCH positively and negatively. Browse below to find the ZWILCH antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ZWILCH Infographic by Boster Bio

All ZWILCH Products

Product

Figures

Specificity

Applications

Price

Human ZWILCH Recombinant Protein

SDS-PAGE

$250
Cat # PROTQ9H900
Starting from 10ug

ZWILCH (NM_017975) Human Over-expression Lysate

Human

$960
Cat # LS055055
100 µg

ZWILCH Overview

Facts about Protein zwilch homolog.

ZWILCH 3D structure

ZWILCH 3D structure. Source: alphafold

Protein zwilch homolog (ZWILCH)

Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes on kinetochores.

Its function related to the spindle assembly machines is proposed to rely on its association from the mitotic RZZ complicated (PubMed:15824131). .

Gene Information

Human
Gene Name:	ZWILCH
Uniprot:	Q9H900
Entrez:	55055

Gene Information

Family

Belongs to:

ZWILCH family

Family

Alternative Names

dJ337O18.5; SWIM domain containing 1; zinc finger, SWIM-type containing 1

Molecular Weight

Mass (kDA):
67.214 kDA

Molecular Weight

Genomic Context


Human

Location:	15q22.31
Sequence:	15; NC_000015.10 (66505083..66550130)

Subcellular Localizations

Chromosome, centromere, kinetochore.

Subcellular Localization

Diseases

Aneuploidy
Misalignment
Instabilities, Chromosomal
Neoplasm Metastasis
Malignant Neoplasms
Neoplasms
Metastatic Malignant Neoplasm To The Lymph Node

Malignant Neoplasm Of Breast
Mammary Neoplasms

Disease

Interacting Proteins

KNTC1

Interacting Proteins

Pathways

Localization
Chromosome Segregation
Metaphase
Anaphase
Spindle Checkpoint
Mitosis
Spindle Assembly Checkpoint
Kinetochore Localization
Spindle Assembly
Transport
Cell Cycle

Kinetochore Assembly
Vesicle Transport
Cell Cycle Arrest
Cytokinesis
Female Meiosis
Meiosis

Pathways

PTMs

Phosphorylation

Research Areas

Mitotic Regulators
Stem Cell Markers

Research Areas

Bosterbio | ELISA Kits, Antibodies, Antibody Company

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ZWILCH

References

PMID: 12686595 by Williams B.C., et al. Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions.

PMID: 15126332 by Wang Z., et al. Three classes of genes mutated in colorectal cancers with chromosomal instability.