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ZW10 Antibodies
AND ZW10 ELISA kits, ZW10 Proteins
Many biological assays use antibodies to detect ZW10, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ZW10 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ZW10 antibodies...
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ZW10 Overview
Facts about Centromere/kinetochore protein zw10 homolog.
Centromere/kinetochore protein zw10 homolog (ZW10)
Essential component of the mitotic checkpoint, which prevents cells from exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes on kinetochores.
Its function linked to the spindle assembly machinery is proposed to depend on its association from the mitotic RZZ complicated (PubMed:11590237, PubMed:15485811, PubMed:15824131). Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the role is proposed to depend on its association in the interphase NRZ complicated which is thought to play a role in SNARE assembly at the ER (PubMed:15029241).
Gene Information
| Human | |
|---|---|
| Gene Name: | ZW10 |
| Uniprot: | O43264 |
| Entrez: | 9183 |
Family
| Belongs to: |
|---|
| ZW10 family |
Alternative Names
E3 ubiquitin-protein ligase ZSWIM2; EC 6.3.2.-; MEKK1-related protein X; MEX; MGC33890; Zinc finger SWIM domain-containing protein 2; zinc finger, SWIM domain containing 2; zinc finger, SWIM-type containing 2; ZZZ2ZZ-type zinc finger-containing protein 2
Molecular Weight
Mass (kDA):
88.829 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q23.2 |
| Sequence: | 11; NC_000011.10 (113733183..113773699, complement) |
Tissue Specificity
Widely expressed.
Subcellular Localizations
Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Dynamic pattern of localization during the cell cycle. In most cells at interphase, present diffusely in the cytoplasm (PubMed:15029241). In prometaphase, associated with the kinetochore. At metaphase, detected both at the kinetochores and, most prominently, at the spindle, particularly at the spindle poles. In very early anaphase, detected on segregating kinetochores. In late anaphase and telophase, accumulates at the spindle midzone (PubMed:11590237).
Diseases
- Aneuploidy
- Malignant Neoplasms
- Limb Deformities, Congenital
- Instabilities, Chromosomal
- Congenital Abnormality
- Melanoma
- Malignant Neoplasm Of Breast
- Genomic Instability
- Growth Retardation
- Misalignment
Interacting Proteins
- RINT1
- ZWINT
Pathways
- Localization
- Mitosis
- Metaphase
- Anaphase
- Chromosome Segregation
- Spindle Checkpoint
- Kinetochore Localization
- Transport
- Interphase
- Spindle Assembly
- Spindle Assembly Checkpoint
- Cell Cycle
- Rna Interference
PTMs
- Phosphorylation
- Dephosphorylation
Research Areas
- Mitotic Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ZW10
bosterbio.com/bosterbio-gene-info-cards/ZW10
References
PMID: 9298984 by Starr D.A., et al. Conservation of the centromere/kinetochore protein ZW10.
PMID: 11590237 by Scaeerou F., et al. The ZW10 and Rough Deal checkpoint proteins function together in a large, evolutionarily conserved complex targeted to the kinetochore.