ZNF598 Antibodies

AND ZNF598 ELISA kits, ZNF598 Proteins

Many biological assays use antibodies to detect ZNF598, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ZNF598 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ZNF598 antibodies...

We validate the specificity of these antibodies to ZNF598 by testing them on tissues known to express ZNF598 positively and negatively. Browse below to find the ZNF598 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ZNF598 Infographic by Boster Bio

All ZNF598 Products

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Anti-Phospho ZFP598 (Tyr306) ZNF598 Antibody

1 Q&As

Human, Mouse

ELISA, IHC-P, WB, IF (paraffin)

$335
Cat # P15343
100ul

Anti-Phospho-ZFP598 (Y306) ZNF598 Antibody

Human, Mouse

ELISA, IHC, WB

$380
Cat # A15343Y306
100ul

ZNF598 (NM_178167) Human Over-expression Lysate

Human

$628
Cat # LS090850
100 µg

ZNF598 Overview

Facts about E3 ubiquitin-protein ligase ZNF598.

ZNF598 3D structure. Source: alphafold

E3 ubiquitin-protein ligase ZNF598 (ZNF598)

E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that happens when a ribosome has stalled during translation (PubMed:28065601, PubMed:28132843). Required for ribosomes to stall during translation of poly(A) sequences by mediating monoubiquitination of 40S ribosomal protein RPS10/eS10, RPS20/uS10 and RPS3/uS3 (PubMed:28065601, PubMed:28132843).

Stalling precludes synthesis of a long poly-lysine tail and initiates the RQC pathway to degrade the possibly harmful aberrant nascent polypeptide (PubMed:28065601, PubMed:28132843). Also acts as a component of the 4EHP-GYF2 complicated, a multiprotein complex that functions as a repressor of translation initiation (PubMed:22751931).

Gene Information

Human
Gene Name:	ZNF598
Uniprot:	Q86UK7
Entrez:	90850

Family

Belongs to:

ZNF598 family

Alternative Names

DKFZp762F135; FLJ00086; zinc finger protein 598

Molecular Weight

Mass (kDA):
98.637 kDA

Genomic Context


Human

Location:	16p13.3
Sequence:	16; NC_000016.10 (1997654..2009821, complement)

Pathways

Translation

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ZNF598

References

PMID: 22751931 by Morita M., et al. A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development.

PMID: 28065601 by Juszkiewicz S., et al. Initiation of quality control during poly(A) translation requires site-specific ribosome ubiquitination.