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- Table of Contents
Facts about Zinc finger CCCH-type with G patch domain-containing protein.
Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its capacity to repress genes of the EGFR pathway indicate it might act as a tumor suppressor.
Human | |
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Gene Name: | ZGPAT |
Uniprot: | Q8N5A5 |
Entrez: | 84619 |
Belongs to: |
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No superfamily |
GPATC6G patch domain-containing protein 6; GPATCH6Zinc finger and G patch domain-containing protein; KIAA1847Zinc finger CCCH domain-containing protein 9; MGC44880; ZC3H9FLJ14972; ZC3HDC9dJ583P15.3; zinc finger, CCCH-type with G patch domain; ZIPzinc finger CCCH-type with G patch domain-containing protein
Mass (kDA):
57.359 kDA
Human | |
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Location: | 20q13.33 |
Sequence: | 20; NC_000020.11 (63707442..63736142) |
Widely expressed.
Nucleus.; [Isoform 4]: Nucleus.
PMID: 19644445 by Li R., et al. ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis.
PMID: 20233718 by Yu W., et al. sZIP, an alternative splice variant of ZIP, antagonizes transcription repression and growth inhibition by ZIP.