Kirrel3 Antibodies

AND Kirrel3 ELISA kits, Kirrel3 Proteins

Many biological assays use antibodies to detect Kirrel3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Kirrel3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Kirrel3 antibodies...

We validate the specificity of these antibodies to Kirrel3 by testing them on tissues known to express Kirrel3 positively and negatively. Browse below to find the Kirrel3 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Kirrel3 Infographic by Boster Bio

All Kirrel3 Products

Product

Figures

Specificity

Applications

Price

Anti-Kin of IRRE-like protein 3 KIRREL3 Antibody

Human, Mouse, Rat

ELISA, IF, IHC-P, WB

$449
Cat # A07202
0.1 mg

KIRREL 3 (KIRREL3) (NM_032531) Human Recombinant Protein

$1249
Cat # PROTQ8IZU9
20 µg

KIRREL 3 (KIRREL3) (NM_032531) Human Over-expression Lysate

Human

$628
Cat # LS084623
100 µg

Kirrel3 Overview

Facts about Kin of IRRE-like protein 3.

Kin of IRRE-like protein 3 (Kirrel3)

Synaptic adhesion molecule necessary for the formation of target-specific synapses (PubMed:23637329, PubMed:26575286). Required for formation of target-specific synapses at hippocampal mossy fiber synapses.

Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably functions as a homophilic adhesion molecule that boosts trans-cellular interactions and stabilize mossy fiber filipodia contact and following synapse formation (PubMed:26575286).

Gene Information

Mouse
Gene Name:	Kirrel3
Uniprot:	Q8BR86
Entrez:	67703

Family

Belongs to:

immunoglobulin superfamily

Alternative Names

KIAA1867MGC126824; kin of IRRE like 3 (Drosophila); Kin of irregular chiasm-like protein 3; kin of IRRE-like protein 3; KIRRE; Kirrel3; KIRREPRO4502; mKIRRE; MRD4; NEPH2; NEPH2MGC126850; nephrin-like 2; Nephrin-like protein 2

Molecular Weight

Mass (kDA):
85.405 kDA

Genomic Context


Mouse

Location:	9\|9 A4
Sequence:	9;

Tissue Specificity

Expressed mainly in adult brain, bone marrow and stromal cells (PubMed:12665856). Expressed in diverse regions of the brain, including the cortex, hippocampus, striatum, olfactory bulb and cerebellum (PubMed:15908127, PubMed:26283919). In brain, expressed in pontine nucleus neurons (at protein level) (PubMed:21241806). In hippocampus, produced in both the dentate granule neurons and the GABAergic neurons, but not the CA3 neurons (PubMed:26575286). Expressed in subpopulations of vomeronasal sensory neurons (PubMed:23637329). Expressed in a subset of neurons in dorsal root ganglia (PubMed:18752272).

Diseases

Tissue Adhesions
Proteinuria Of Undiagnosed Cause
Nervousness
Nephrotic Syndrome
Autistic Disorder
Congenital Nephrotic Syndrome
Muscular Fasciculation
Jacobsen Distal 11q Deletion Syndrome
Schizophrenia
Kidney Failure
Language Delays

Mental Disorders
Child Development Disorders, Pervasive
Congenital Anomaly Of Brain
Kidney Diseases
Chromosomal Translocation
Chromosome Breakage

Pathways

Cell Recognition
Glomerular Filtration
Cell-cell Adhesion
Cell Adhesion
Cell Death
Brain Development
Myoblast Fusion

Axonal Fasciculation

PTMs

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Kirrel3

References

PMID: 12665856 by Ueno H., et al. A stromal cell-derived membrane protein that supports hematopoietic stem cells.

PMID: 15843475 by Gerke P., et al. NEPH2 is located at the glomerular slit diaphragm, interacts with nephrin and is cleaved from podocytes by metalloproteinases.