Abscission/NoCut checkpoint regulator (Zfyve19)

Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a procedure needed to postpone abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to keep abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring before abscission checkpoint signaling is terminated at late cytokinesis.

Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission (By similarity). .