ZCCHC8 Antibodies

AND ZCCHC8 ELISA kits, ZCCHC8 Proteins

Many biological assays use antibodies to detect ZCCHC8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ZCCHC8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ZCCHC8 antibodies...

We validate the specificity of these antibodies to ZCCHC8 by testing them on tissues known to express ZCCHC8 positively and negatively. Browse below to find the ZCCHC8 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ZCCHC8 Infographic by Boster Bio

All ZCCHC8 Products

Product

Figures

Specificity

Applications

Price

Anti-ZCHC8 ZCCHC8 Antibody

Human, Mouse

ELISA, WB

$380
Cat # A10566
100ul

ZCCHC8 (NM_017612) Human Recombinant Protein

$1249
Cat # PROTQ6NZY4
20 µg

ZCCHC8 (NM_017612) Human Over-expression Lysate

Human

$628
Cat # LS055596
100 µg

ZCCHC8 Overview

Facts about Zinc finger CCHC domain-containing protein 8.

ZCCHC8 3D structure. Source: alphafold

Zinc finger CCHC domain-containing protein 8 (ZCCHC8)

Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non- coding short lived RNAs for exosomal degradation. The RNA exosome is essential for the degradation of RNA in eukaryotic nuclei.

Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484). May be involved in pre-mRNA splicing (Probable).

Gene Information

Human
Gene Name:	ZCCHC8
Uniprot:	Q6NZY4
Entrez:	55596

Family

Belongs to:

ZCCHC8 family

Alternative Names

DKFZp434E2220; zinc finger CCHC domain-containing protein 8; zinc finger, CCHC domain containing 8

Molecular Weight

Mass (kDA):
78.577 kDA

Genomic Context


Human

Location:	12q24.31
Sequence:	12; NC_000012.12 (122471600..122501184, complement)

Subcellular Localizations

Nucleus, nucleoplasm. Nucleus. Excluded from nucleolus.

Diseases

Neuroblastoma
Malignant Neoplasms
Neoplasms
Nervousness

Interacting Proteins

BRCA1

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ZCCHC8

References

PMID: 16263084 by Gustafson M.P., et al. Zcchc8 is a glycogen synthase kinase-3 substrate that interacts with RNA-binding proteins.

PMID: 21855801 by Lubas M., et al. Interaction profiling identifies the human nuclear exosome targeting complex.